Biomedical research involving nanoparticles has produced useful products with medical applications. However, the potential toxicity of nanoparticles in biofluids, cells, tissues, and organisms is a major challenge. The '-omics' analyses provide molecular profiles of multifactorial biological systems instead of focusing on a single molecule. The 'omics' approaches are necessary to evaluate nanot...

The iron oxide nanoparticles (FeNPs) are widely used in biomedicine for good biocompatibility. To promote its safe application, any potential nanotoxicity should be thoroughly and carefully investigated. This paper systematically summarizes our lab’s research on the nanotoxicity of iron oxide nanoparticles coated with dimercaptosuccinic acid (DMSA), including the effects of FeNPs on viability, ...

Supratik Kar 1, Juganta K. Roy 1, Danuta Leszczynska 2 and Jerzy Leszczynski 1,* 1 Interdisciplinary Center for Nanotoxicity, Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA; [email protected] (S.K.); [email protected] (J.K.R.) 2 Interdisciplinary Center for Nanotoxicity, Department of Civil and Environmental Engineering, Jackson State...

Nanosafety has been a subject of scrupulous indagation attributed to the ambiguity in terms harmonizing and perceiving nano risk evaluation. Nanotoxicity is an emanate pigeonhole nanotechnology. The burgeoning commercial products grafted with engineered nanomaterials escalated exponentially. Inevitably, profile their repercussions on ecosystem mankind must be meticulously assessed. research fra...

Nanoparticles are generally dispersed in electrolyte solutions for cell research. They may be aggregated and thus strongly influence the subsequent bio-effects. However, this has been often neglected in nanotoxicity research. In this paper, we selected gold nanoparticles as an example and investigated the role of dispersity in cytotoxicity. Our data indicated that the cytotoxicity of aggregated...

Traditional in vitro nanotoxicity researches are conducted on cultured two-dimensional (2D) monolayer cells and thereby cannot reflect organism response to nanoparticle toxicities at tissue levels. This paper describes a new, high-throughput approach to test in vitro nanotoxicity in three-dimensional (3D) microtissue array, where microtissues are formed by seeding cells in nonsticky microwells,...

BACKGROUND Iron nanoparticles (FeNPs) have attracted increasing attention over the past two decades owing to their promising application as biomedical agents. However, to ensure safe application, their potential nanotoxicity should be carefully and thoroughly evaluated. Studies on the effects of FeNPs on cells at the transcriptomic level will be helpful for identifying any potential nanotoxicit...