نتایج جستجو برای: Nanostructured lipid carriers

تعداد نتایج: 220080  

2002
RAINER H. MÜLLER

solid lipid carriers – NLC. Particulate lipid matrices in the form of lipid pellets are known from the textbooks since many years, products are on the market (e. g. Mucosolvan retard, Boehringer-Ingelheim). After these lipid pellets as the first generation, P. Speiser developed so-called “lipid nanopellets for oral administration” in the middle of the eighties [1]. This system was not further d...

2012
Min Fang Yilin Jin Wei Bao Hui Gao Mengjin Xu Di Wang Xia Wang Ping Yao Liegang Liu

BACKGROUND Curcumin has a variety of pharmacological effects. However, poor water solubility and low oral bioavailability limit its clinical utility. A delivery system for nanostructured lipid carriers has been reported to be a promising approach to enhancing the oral absorption of curcumin. The aim of the present study was to investigate the pharmacokinetics, tissue distribution, and relative ...

سعیدی, مجید, اکبری, جعفر, کلیدری, حمیدرضا,

Nowadays solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been investigated as carrier systems for many applications. SLNs consist of pure solid lipids, while NLCs are made of a solid matrix that entraps liquid lipid nano-compartments. These systems revealed several advantages compared to other colloidal carrier systems. They provide a controlled drug release and an ...

Journal: :Asian Journal of Pharmaceutical Sciences 2016

2016
Ji Wang Yu-Xia Kang Wen Pan Wan Lei Bin Feng Xiao-Juan Wang

Macrophages are one kind of innate immune cells, and produce a variety of inflammatory cytokines in response to various stimuli, such as oxidized low density lipoprotein found in the pathogenesis of atherosclerosis. In this study, the effect of phosphatidylserine on anti-inflammatory activity of curcumin-loaded nanostructured lipid carriers was investigated using macrophage cultures. Different ...

2016
Neelam Poonia Rajeev Kharb Viney Lather Deepti Pandita

Oral delivery is the most accepted and economical route for drug administration and leads to substantial reduction in dosing frequency. However, this route still remains a challenge for the pharmaceutical industry due to poorly soluble and permeable drugs leading to poor oral bioavailability. Incorporating bioactives into nanostructured lipid carriers (NLCs) has helped in boosting their therape...

Journal: :Nanomedicine : nanotechnology, biology, and medicine 2016
Ana Beloqui María Ángeles Solinís Alicia Rodríguez-Gascón António J Almeida Véronique Préat

During the past decade, the number of studies describing nanostructured lipid carriers (NLCs)-based formulations has been dramatically increased. The raise in NLC exploitation is essentially due to defeated barriers within the technological process of lipid-based nanoparticles' formulation and increased knowledge of the underlying mechanisms of transport of NLCs via different routes of administ...

2011
Mohammed Mehanna Adel Motawaa Magda Samaha

Drug delivery research areas is continuously broaden and modified as a results of the realization of many factors (such as poor drug solubility and/or absorption, rapid metabolism, high fluctuation in the drug plasma level and variability) adversely affect in-vivo results, in conventional drug delivery system. Lipids are one of the basic building blocks of biological membranes. Nanoscale-based ...

2010
Slavomira Doktorovova Carla Martins Lopes Eliana B. Souto

colloidal carriers composed of lipids attract much attention in the development of safer and more effective therapy of various diseases. the advantages of lipid-based nanoparticles are illustrated on the example of paclitaxel, a challenging chemotherapeutic drug for the development of a novel and more suitable dosage form for cancer treatment. paclitaxel is known for its water insolubility and ...

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