نتایج جستجو برای: Nanoprecipitation

تعداد نتایج: 350  

2008
Young-Il Jeong Don-Gon Kim Mi-Kyeong Jang Jae-Woon Nah

In this study, we prepared all-trans retinoic acid (ATRA)-encapsulated, surfactant-free, PLGA nanoparticles. The nanoparticles were formed by nanoprecipitation process, after which the solvent was removed by solvent evaporation or dialysis method. When a nanoparticle was prepared by the nanoprecipitation solvent evaporation method, the nanoparticles were bigger than the nanoparticles of the nan...

Journal: :Advanced pharmaceutical bulletin 2014
Moorthi Chidambaram Kathiresan Krishnasamy

PURPOSE Nanoprecipitation is the convenient and commonly used method for the preparation of polymeric nanoparticles around 170 nm but yield particles with broad distribution, which require filtration step to produce particles with narrow distribution. Hence, the primary aim of the present study was to implement few modifications to the conventional nanoprecipitation method to reduce the mean pa...

2012
Moraima Morales-Cruz Giselle M. Flores-Fernández Myreisa Morales-Cruz Elsie A. Orellano José A. Rodriguez-Martinez Mercedes Ruiz Kai Griebenow

One of the first methods to encapsulate drugs within polymer nanospheres was developed by Fessi and coworkers in 1989 and consisted of one-step nanoprecipitation based on solvent displacement. However, proteins are poorly encapsulated within polymer nanoparticles using this method because of their limited solubility in organic solvents. To overcome this limitation, we developed a two-step nanop...

2017
Junli Zhou Ying Chau

We here report an easy and efficient strategy to prepare submicron-sized polymeric vesicles with tetrahydrofuran (THF) as a good solvent through temperature-assisted nanoprecipitation (TAN). While conventional nanoprecipitation did not yield vesicles from block co-polymers (PEG-b-PCL), TAN produced vesicles with morphology and membrane thickness similar to those obtained by film rehydration met...

2008
P. Basto F. Gu L. Zhang C. Cannizzaro R. Langer O. Farokhzad R. Karnik

We report the use of microfluidic rapid mixing using hydrodynamic flow focusing to control the self-assembly of polymeric nanoparticles (NPs) that can be used for drug delivery. PLGA-PEG polymeric NPs and PLGA-lipid hybrid NPs were synthesized through nanoprecipitation—a process that involves dilution of a block copolymer from a solvent to an anti-solvent resulting in the precipitation of NPs. ...

2015
Jonathan P. Salvage Christopher Thom Andrew L. Lewis Gary J. Phillips Andrew W. Lloyd

Biodistribution of nanoparticle-based intracellular delivery systems is mediated primarily by particle size and physicochemical properties. As such, overcoming the rapid removal of these by the reticuloendothelial system remains a significant challenge. To date, a number of copolymer nanoparticle systems based on 2-methacryloyloxyethyl phosphorylcholine (MPC) with 2-(diisopropylamino)ethyl meth...

Journal: :Biomaterials 2010
Rong Tong Linda Yala Timothy M Fan Jianjun Cheng

Paclitaxel-polylactide (Ptxl-PLA) conjugate nanoparticles, termed as nanoconjugates (NCs), were prepared through Ptxl/(BDI)ZnN(TMS)(2) (BDI = 2-((2,6-diisopropylphenyl)-amido)-4-((2,6-diisopropylphenyl)-imino)-2-pentene)-mediated controlled polymerization of lactide (LA) followed by nanoprecipitation. Nanoprecipitation of Ptxl-PLA resulted in sub-100 nm NCs with monomodal particle distributions...

Journal: :Chemical communications 2015
Hailong Fan Zhaoxia Jin

We demonstrated a one-pot, soap-free fabrication of porous polycaprolactone microspheres by combining nanoprecipitation and hydrolysis. The obtained porous polycaprolactone microspheres show great advantages for application in drug delivery.

2014
Qin Wang Puyuan Wu Wei Ren Kai Xin Yang Yang Chen Xie Chenchen Yang Qin Liu Lixia Yu Xiqun Jiang Baorui Liu Rutain Li Lifeng Wang

To establish a satisfactory delivery system for the delivery of salinomycin (Sal), a novel, selective cancer stem cell inhibitor with prominent toxicity, gelatinase-responsive core-shell nanoparticles (NPs), were prepared by nanoprecipitation method (NR-NPs) and single emulsion method (SE-NPs). The gelatinase-responsive copolymer was prepared by carboxylation and double amination method. We stu...

Journal: :Biomaterials science 2017
Qing Pei Xiuli Hu Junli Zhou Shi Liu Zhigang Xie

Paclitaxel dimer-based nanovesicles, with an ultrahigh drug content, have been prepared through a nanoprecipitation method. The as-formed nanovesicles exhibit improved paclitaxel solubility, prominent colloid stability, GSH-triggered disassembly, effective cellular uptake and comparable cytotoxicity to Taxol.

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