نتایج جستجو برای: Nanonization
تعداد نتایج: 19 فیلتر نتایج به سال:
Nanonized progesterone formulation for improved oral bioavailability in healthy and pregnant rabbits
The aim of this study is to evaluate and compare the oral bioavailability nanonized progesterone (nano-PG) micronized (micro-PG) sustained release tablet formulation in healthy pregnant rabbits. High pressure compressed gas technology reduces particle size from 1.72 ± 2.5 μm 800 35 nm (nano-PG). DSC XRD showed that both micro-PG nano-PG were crystalline exist as form I. Higher melting enthalpy ...
Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major nanonization techniques that seek to overcome these limita...
The aim of this study was to produce niflumic acid nanoparticles without using an organic solvent, in order to achieve an increased rate of dissolution of the final products. Co-grinding with excipients was used to decrease the particle size. Poloxamer 188 (P) and mannitol (M) applied as co-grinding materials stabilized the system, preventing aggregation of the nanocrystals. The morphology and ...
Poor water solubility remains main culprit for the formulation scientist which can be overcome by nanonization. Nanoemulsion is kinetically stable and isotropic system of two immiscible liquids in sub microne size range. Nanoemulsions are composed of oil droplets dispersed in an aqueous medium and stabilized by surfactant molecules. Advantages of nanoemulsions include increased drug loading and...
Many techniques have been developed to overcome the bioavailability problem of poorly soluble drugs. The nanonization is one in that micronized particle converted nanoparticle. Several processes are applied for nanocrystal production, including precipitation, milling, high pressure homogenization and combination method. formulation administered via various routes like oral, intravenous, intramu...
Utilization of LiFePO4 as a cathode material for Li-ion batteries often requires size nanonization coupled with calcination-based carbon coating to improve its electrochemical performance, which, however, is usually at the expense of tap density and may be environmentally problematic. Here we report the utilization of micron-sized LiFePO4, which has a higher tap density than its nano-sized sibl...
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