A perm-selective nanochannel could initiate concentration polarization near the nanochannel, significantly decreasing (increasing) the ion concentration in the anodic (cathodic) end of the nanochannel. Such strong concentration polarization can be induced even at moderate buffer concentrations because of local ion depletion (therefore thicker local Debye layer) near the nanochannel. In addition...

Nanochannel conductance measurements are commonly performed to characterize nanofluidic devices Theoretical analysis and experimental investigations imply that the nanochannel conductance does not follow the macro-scale models. It is generally accepted that the conductance of nanochannels deviates from the bulk and trend to a constant value at low concentrations. In this work, we present an imp...

Heterogeneous nanochannel materials that endow new functionalities different to the intrinsic properties of two original nanoporous materials have wide potential applications in nanofluidics, energy conversion, and biosensors. Herein, we report novel, interesting hydrogel-composited nanochannel devices with regulatable ion rectification characteristics. The heterogeneous nanochannel devices wer...

Nanochannel based devices have been widely used for single-molecule detection. The detection usually relies on the resistive-pulse model, where the change of the monitored current depends on the physical volumetric blocking of the nanochannel by the analyte. However, this mechanism requires that the nanochannel diameter should not be much larger than the analyte size, because, otherwise, the re...

Nanofabrication technologies have been a strong advocator for new scientific fundamentals that have never been described by traditional theory, and have played a seed role in ground-breaking nano-engineering applications. In this study, we fabricated ultra-high-aspect (∼10(6) with O(100) nm nanochannel opening and O(100) mm length) orthogonal nanochannel array using only polymeric materials. Ve...

Nanofluidic systems are attracting a great deal of interest due to their fundamental significance and potential applications in chemistry, biology and physics. However, high fabrication cost, expensive equipments and complicated fabrication process of most current fabrication techniques prevent lots of researchers from entering the nanofluidic field. Here we present a quick, simple and costeffe...

A simple biomimetic mercury(II)-gated single nanochannel has been developed by incorporating a mercury(II) responsive single stranded DNA (ssDNA) with thymine-thymine (T-T) bases into a single polymetic nanochannel.

Driving single nanoparticles like DNA and proteins by the electrophoretic force through a nanopore in the presence of an electric field produces an ionic current, which passes from the nanopore. The current blockage due to the nanoparticle translocation makes an observable change in the ionic current, which is useful for the study of bio molecules. Many efforts are made to perceive the electro ...

Transmembrane proteins are mostly nanochannels playing a highly important role in metabolism. Understanding their structures and functions is vital for revealing life processes. It is of fundamental interest to develop chemical devices to mimic biological channels. Structural DNA nanotechnology has been proven to be a promising method for the preparation of fine DNA nanochannels as a result of ...

Chromatographic separation and detection of nonfluorescent molecules were integrated in a nanochannel. Our method, extended-nano chromatography realized high-performance separation using pressure-driven flow in a 100-nm scale nanochannel. A photothermal detector, differential interference contrast thermal lens microscope (DIC-TLM) was employed for detection of nonfluorescent samples. In particu...