Whole-body and single photon emission tomography (SPET) images during sodium iodide-131 (Na131I) ablation are useful to confirm the efficacy of ablation using 131I imaging. However, there have been no attempts to improve the quality of 131I imaging. We therefore investigated imaging protocols for 131I imaging in differentiated thyroid cancer (DTC). Phantoms containing 131I were used to simulate...

Specific molecular probes are essential for the early diagnosis of prostate cancer. In addition, peptides have been shown to have numerous uses as diagnostic and therapeutic molecular probes. The K237 peptide binds to the vascular endothelial growth factor receptor with high affinity and specificity, and was predicted to have potential use as a probe in tumor angiogenesis. The overall aim of th...

contamination with radiopharmaceuticals in nuclear medicine centers in addition to being a health concern requires time-consuming decontamination efforts. according to nrc (nuclear regulatory commission) contamination should be monitored in nuclear medicine centers where radiopharmaceuticals are prepared and administrated at the end of each working session; otherwise, contamination spread to ot...

The basic sensitivity of the Limulus test and the inhibitory factors were examined in 21 radiopharmaceuticals commonly used in Japan. The sensitivity of the Limulus test using pre-gel was found to be 1 mug/ml for Escherichia coli endotoxin. This sensitivity is about ten times that of the rabbit test adopted by USP and JP. The Limulus test was applicable, with full sensitivity and without inhibi...

A terminally ill patient with metastatic thyroid cancer and severe renal insufficiency was treated as an inpatient with 10,545 MBq (285 mCi) Na131I. The patient died six days after radiopharrnaceutical administration while still in the hospital. A close relative of the patient disregarded the instructions of the Radiation Safety Officer (RSO) and insisted upon staying close to the patient for l...

Kidney weight was significantly decreased in hypothyroidism (induced by Na131I administration) and increased in hyperthyroidism (induced by thyroxine treatment) as compared to control in female Wistar rats. The tissue lipid peroxidation level remained unchanged in hyperthyroid rats but significantly increased in hypothyroid rats. Superoxide dismutase was decreased in both experimental groups bu...

Stable and unstable isotopes of the heavy noble gas xenon find use in various medical applications. However, apart from 133Xe, used for Single Photon Emission Computed Tomography, radioactive are currently complicated to obtain small quantities. With GAMMA-MRI project mind, we investigated a thermal sublimation generator long-lived excited state (isomer) 131mXe. This production method utilized ...