background & aim: the present study aimed to evaluate  the frequency and severity of nausea and vomiting during pregnancy (nvp) and to investigate the association between psychosocial health and the severity of nvp. methods:this cross-sectional study was performed on 200 eligible pregnant women with nausea and vomiting at three prenatal care centers in kashan, iran. the participants completed d...

The hydrophilic-lipophilic balance (HLB) polymers are able to directly extract polar and non-polar analytes from the aqueous samples, making them very popular for analytical separation SPE applications. However, commonly used suspension polymerization method preparing HLB is only efficiently prepare with low or medium mol percentages of hydrophilic monomer due partitioning into phase at higher ...

INTRODUCTION Nevirapine (NVP) resistance may decrease the effectiveness of viral suppression with NVP-based antiretroviral therapy (ART) in women infected with human immunodeficiency virus (HIV) with previous exposure to single-dose NVP. However, the alternative lopinavir-ritonavir-based ART regimen is more expensive. Our objectives were to project the tradeoffs regarding life expectancy, cost,...

Technology search is crucial to establishing competitive advantage and improving firm performance. However, it still unclear how different technology strategies affect performance at the level determine in dynamic environments. Therefore, based on resource-based theory, this study explores relationship between digital search, advantage, new venture (NVP) environments with a sample of 267 Chines...

BACKGROUND & OBJECTIVE Incomplete adherence is a major contributor to failure of antiretroviral therapy. Although the available methods to monitor adherence to therapy have proved to be predictive of outcomes, the results are variable. We assessed the feasibility of detecting nevirapine (NVP) in spot urine samples to monitor patient adherence to antiretroviral treatment and to study the urinary...

An extended-release formulation of nevirapine (NVP-XR) has been developed with the aim of simplifying antiretroviral treatment regimens and improving patients' adherence with a single daily intake. The VERxVE and TRANxITION clinical trials have demonstrated the noninferiority of NVP-XR compared with nevirapine immediate-release (NVP-IR) on viral load after 24 and 48 months of treatment. The tol...

Background Wk 24 TRANxITION study data showed patients transitioned from immediate release nevirapine (NVP IR) twice daily (BID) to NVP extended release (NVP XR) once-daily (QD) demonstrated non-inferior efficacy to patients continuing on IR NVP BID [1]. Similar safety was reported for NVP XR and NVP IR in the VERxVE study [2]. Wk 48 efficacy/safety data from TRANxITION study are presented here.

NVP-BKM120, a potent and highly selective PI3K inhibitor, is currently being investigated in phase I/II clinical trials. The mechanisms of action of NVP-BKM120 in colon cancer cells are unclear. In the present study, we investigated how NVP-BKM120 suppresses colon cancer cells growth and potentiates effects of other chemotherapeutic drugs. We found that NVP-BKM120 treatment enhance PUMA inducti...

Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used against HIV-1. Currently, NVP is the most widely used anti-HIV drug in developing countries, both in combination therapy and to prevent mother-to-child transmission of HIV. Despite its efficacy against HIV, NVP produces a variety of toxic responses, including hepatotoxicity and skin rash. It is also associated wit...