15 2DTA 2NTA NTA p MITL k U k DTA Figure 5: Relationship between various classes Theorem 5.2 The membership problem for 2NTA is solvable in PSPACE. Proof. Consider a 2NTA A, and let k be the magnitude of the largest constant appearing in a clock constraint in the transitions of A. Given a timed word w = (;) of length n, deene R w to be the set comprising of i + c and (i + j + c)=2 for 1 i; j n ...

We investigated the induction of renal tumors by the ferric complex of nitrilotriacetic acid (Fe-NTA) in male and female A/J mice. Fifty-three male and 21 female mice received i.p. injections of Fe-NTA, 1.8 to 2.7 mg of iron/kg of body weight/day, 6 days a wk for 12 wk, at the longest. Ten male and ten female mice received nitrilotriacetic acid (NTA) i.p. at the dose equivalent to the NTA porti...

Among the various molecular interactions used to construct supramolecular self-assembling systems, homoliganded metallic NTA-Ni-NTA complexes have received little attention despite their considerable potential applications, such as the connection of different biochemical functions. The stability of this complex is investigated here by using two concordant nanotechniques (surface forces apparatu...

Administration of ferric nitrilotriacetate (Fe-NTA) in vivo causes acute renal tubular injury and finally induces renal cell carcinoma. There is accumulating evidence that these processes involve free radicals generated by Fe-NTA. To study the mechanism of renal carcinogenesis by Fe-NTA, we attempted to induce malignant transformation of primary cultured renal cells by treatment with Fe-NTA. Wh...

Bioassays for the carcinogenicity of nitrilotriacetic acid, trisodium salt, monohydrate (Na3-NTA-H2O) were conducted at Stanford Research Institute (SRI), using Fischer 344 rats and at Litton Bionetics, Inc. (LBI), using both Fischer 344 rats, and B6C3F1 mice. Similar bioassays using rats and mice, were conducted at LBI on the free acid, nitrilotriacetic acid (NTA). Each chemical was mixed in r...

A strain of SHR, which spontaneously develops hypertension and cardiovascular diseases, had a decreasing number of rosette forming T-cells in their thymuses and a progressive decline in cellular immune functions such as blastogenic responses to PHA, delayed type hypersensitivity and allograft rejections by aging (Takeichi et al., Clin. exp. Immunol., 40: 120, 1980). A cell cooperation experimen...

This work describes the synthesis and use of the chelator lipid, nitrilotriacetic acid ditetradecylamine (NTA-DTDA). This lipid is readily dispersed in aqueous media, both alone and when mixed with carrier lipids like dimyristoylphosphatidylcholine (DMPC). Fluorescence microscopic examination of membranes deposited from NTA-DTDA-containing liposomes shows that NTA-DTDA mixes uniformly with the ...

A previous study has shown that a single injection of ferric nitrilotriacetate (Fe-NTA) produces hepatic parenchymal iron loading in rats. The present paper reports on iron uptake by rat liver and iron toxicity in the liver after a single injection of Fe-NTA (7.5 mg Fe/kg B.W.). Iron uptake was examined with 59Fe-NTA and Fe-[14C]-NTA. Thirty percent of the injected 59Fe was incorporated in the ...

The interaction between noncoding endogenous target mimicry (eTM) and its corresponding microRNA (miRNA) is a newly discovered regulatory mechanism and plays pivotal roles in various biological processes in plants. Tobacco (Nicotiana tabacum) is a model plant for studying secondary metabolite alkaloids, of which nicotine accounts for approximately 90%. In this work, we identified four unique to...