نتایج جستجو برای: NPH insulin

تعداد نتایج: 183665  

Journal: :Diabetes care 2000
J Rosenstock G Park J Zimmerman

OBJECTIVE Insulin glargine (HOE 901, 21(A)-Gly-30(B)a-L-Arg-30(B)b-L-Arg human insulin) is a novel recombinant analog of human insulin with a shift in the isoelectric point producing a retarded absorption rate and an increased duration of action that closely mimics normal basal insulin secretion. It recently received approval from the Food and Drug Administration. The aim of this study was to e...

Journal: :Diabetes care 2004
Wieland Kiess Klemens Raile Angela Galler Thomas Kapellen

OBJECTIVE Insulin detemir is a soluble long-acting basal insulin analog designed to overcome the limitations of conventional basal insulin formulations. Accordingly, insulin detemir has been compared with NPH insulin with respect to glycemic control (HbA1c, prebreakfast glucose levels and variability, and hypoglycemia) and timing of administration. RESEARCH DESIGN AND METHODS People with type...

Journal: :Journal of the American Geriatrics Society 2012
Pearl Lee Annette Chang Caroline Blaum Aleksandra Vlajnic Ling Gao Jeffrey Halter

OBJECTIVES To compare the safety and efficacy of adding insulin glargine or neutral protamine Hagedorn (NPH) insulin to existing oral antidiabetic drug (OAD) regimens in adults with type 2 diabetes mellitus. DESIGN Pooled analysis of data from five randomized controlled trials with similar designs. SETTING Three hundred forty-two centers in more than 30 countries worldwide. PARTICIPANTS R...

Journal: :Diabetes care 2000
R E Ratner I B Hirsch J L Neifing S K Garg T E Mecca C A Wilson

OBJECTIVE Insulin glargine (21A-Gly-30Ba-L-Arg-30Bb-L-Arg-human insulin) is a biosynthetic insulin analog with a prolonged duration of action compared with NPH human insulin. This study compared insulin glargine with NPH human insulin in subjects with type 1 diabetes who had been previously treated with multiple daily injections of NPH insulin and regular insulin. RESEARCH DESIGN AND METHODS ...

Journal: :Diabetes, obesity & metabolism 2008
Matteo Monami Niccolò Marchionni Edoardo Mannucci

BACKGROUND Long-acting insulin analogues, in comparison with NPH insulin, should warrant a greater reproducibility of absorption after subcutaneous injection, providing better metabolic control with reduced hypoglycaemic risk. Aim of the present meta-analysis is the assessment of differences with respect to HbA1c, incidence of hypoglycaemia, weight gain, between NPH human insulin and each long-...

2014
Björn Eliasson Nils Ekström Sara Bruce Wirta Anders Odén MirNabi Pirouzi Fard Ann-Marie Svensson

INTRODUCTION To investigate the clinical effects associated with premixed insulin (PM) and basal insulin [insulin NPH (NPH), insulin glargine (IG), insulin detemir (ID)], in insulin-naïve patients with type 2 diabetes in routine clinical care. MATERIALS AND METHODS Cohort study based on data from the Swedish National Diabetes Register, including 5,077 patients, resident in the Western region ...

2013
N Thalange A Bereket J Larsen L C Hiort V Peterkova

AIMS This 52-week, randomized, multinational, open-label, parallel-group, non-inferiority trial investigated the efficacy and safety of basal-bolus treatment with insulin detemir vs. NPH (neutral protamine Hagedorn) insulin, in combination with insulin aspart, in subjects aged 2-16 years with Type 1 diabetes mellitus. METHODS Of the 347 randomized and exposed subjects, 177 received insulin de...

Journal: :Diabetes research and clinical practice 2017
David R Owens Louise Traylor Peter Mullins Wolfgang Landgraf

AIMS Evaluate efficacy and hypoglycaemia according to concomitant oral antidiabetes drug (OAD) in people with type 2 diabetes initiating insulin glargine 100U/mL (Gla-100) or neutral protamine Hagedorn (NPH) insulin once daily. METHODS Four studies (target fasting plasma glucose [FPG] ⩽100mg/dL [⩽5.6mmol/L]; duration ⩾24weeks) were included. Standardised data from 2091 subjects (Gla-100, n=10...

Journal: :Diabetes care 2001
J Rosenstock S L Schwartz C M Clark G D Park D W Donley M B Edwards

OBJECTIVE To determine the safety and efficacy of the long-acting analog insulin glargine compared with NPH insulin in patients with type 2 diabetes who were previously treated with insulin alone. RESEARCH DESIGN AND METHODS A total of 518 subjects with type 2 diabetes who were receiving NPH insulin with or without regular insulin for postprandial control were randomized to receive insulin gl...

2010
Jason R. Young Carrie McAdam-Marx

Insulin detemir is a long-acting basal insulin approved for use in patients with type 1 (T1DM) or type 2 diabetes (T2DM). Insulin detemir has demonstrated equivalent glycemic control and hypoglycemic risk when compared to insulin glargine, and insulin detemir has generally but not consistently demonstrated less weight gain than insulin glargine in T2DM. The benefits of basal insulin analogs rel...

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