The National Drug File Reference Terminology (NDF-RT) presents a large set of drug classes which can potentially be used in clincal settings. Using semantic web technologies such as XML (eXtensible Markup Language) and RDF (Resource Description Framework), the drug classes in NDF-RT were enriched for the purpose of comparison to themselves and to drug classes in other terminologies. Methods and...

Clinical and epidemiological researchers across all medical specialties need tools and knowledge representations to support the classification, aggregation, and analysis of medication data. The Veterans Affairs National Drug File Reference Terminology (NDF-RT) is a named standard for classifying medications. We describe our experience applying NDF-RT to aggregate RxNorm-encoded medications that...

BACKGROUND There is limited consensus among drug information sources on what constitutes drug-drug interactions (DDIs). We investigate DDI information in two publicly available sources, NDF-RT and DrugBank. METHODS We acquire drug-drug interactions from NDF-RT and DrugBank, and normalize the drugs to RxNorm. We compare interactions between NDF-RT and DrugBank and evaluate both sources against...

UNLABELLED BACKGROUND Structured Product Labeling (SPL) is a document markup standard approved by Health Level Seven (HL7) and adopted by United States Food and Drug Administration (FDA) as a mechanism for exchanging drug product information. The SPL drug labels contain rich information about FDA approved clinical drugs. However, the lack of linkage to standard drug ontologies hinders their ...

The National Drug File - Reference Terminology (NDF-RT) is a large and complex drug terminology. NDF-RT provides important information about clinical drugs, e.g., their chemical ingredients, mechanisms of action, dosage form and physiological effects. Within NDF-RT such information is represented using tens of thousands of roles. It is difficult to comprehend large, complex terminologies like N...

The Pharmacogenomics Knowledge Base (PharmGKB) [1] is a publicly available central resource for pharmacogenomics data and knowledge, which is being widely employed into clinical practice and thus requires using clinical terminologies. Hence, harmonizing PharmGKB drug data with well annotated drug terminologies will facilitate its integration with other related resources and support data represe...

Biomedical terminology and vocabulary standards (for the purposes of this correspondence , we use the terms 'terminology,' 'vocabulary' and 'ontology' interchangeably.) play an important role in enabling consistent, comparable, and meaningful sharing of data within and across institutional boundaries, as well as ensuring semantic interoperability. An important domain for developing standardized...

Biomedical terminology and vocabulary standards play an important role in enabling consistent, comparable, and meaningful sharing of data within and across institutional boundaries, as well as ensuring semantic interoperability. The Veterans Affairs (VA) National Drug File Reference Terminology (NDF-RT) is a federally recommended standardized terminology resource encompassing medications, ingre...

Clinical and epidemiological researchers across all medical specialties need tools and knowledge representations to support the classification, aggregation, and analysis of medication data. The National Drug File Reference Terminology (NDF-RT), a named standard for classifying medications, is developed by the US Department of Veterans Affairs (VA) as an extension to their National Drug File, wh...

BACKGROUND The RxNorm and NDF-RT (National Drug File Reference Terminology) are a suite of terminology standards for clinical drugs designated for use in the US federal government systems for electronic exchange of clinical health information. Analyzing how different drug products described in these terminologies are categorized into drug classes will help in their better organization and class...