نتایج جستجو برای: N4

تعداد نتایج: 1961  

2012
Mohammad S. Ali Fan-Lin Kong Alex Rollo Richard Mendez Saady Kohanim Daniel Lee Smith David J. Yang

The nitro group of 2-nitroimidazole (NIM) enters the tumor cells and is bioreductively activated and fixed in the hypoxia cells. 1,4,8,11-tetraazacyclotetradecane (N4) has shown to be a stable chelator for (99m)Tc. The present study was aimed to develop (99m)Tc-cyclam-2-nitroimidazole ((99m)Tc-N4-NIM) for tumor hypoxia imaging. N4-NIM precursor was synthesized by reacting N4-oxalate and 1,3-dib...

Journal: :Journal of bacteriology 1988
K Negishi K Tamanoi M Ishii M Kawakami Y Yamashita H Hayatsu

N4-Aminocytidine, a nucleoside analog, is strongly mutagenic to various organisms including Escherichia coli. Using E. coli WP2 (trp), we measured the incorporation of [5-3H]N4-aminocytidine into DNA and at the same time measured the frequency of reversion of the wild type, thereby attempting to correlate the incorporation with mutation induction. First, we observed that N4-aminocytidine uptake...

Journal: :Acta Crystallographica Section E Structure Reports Online 2011

2011
Fan-Lin Kong Mohammad S. Ali Yinhan Zhang Chang-Sok Oh Dong-Fang Yu Mithu Chanda David J. Yang

PURPOSE This study was to develop an efficient synthesis of (99m)Tc-O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-α-methyl tyrosine ((99m)Tc-N4-AMT) and evaluate its potential in cancer imaging. METHODS N4-AMT was synthesized by reacting N4-oxalate and 3-bromopropyl AMT (N-BOC, ethyl ester). In vitro cellular uptake kinetics of (99m)Tc-N4-AMT was assessed in rat mammary tumor cells. Tissu...

Journal: :Discrete Mathematics 2004
Iliya Bouyukliev Markus Grassl Zlatko Varbanov

Let n4(k; d) be the minimum length of a linear [n; k; d] code over GF(4) for given values of k and d. For codes of dimension "ve, we compute the exact values of n4(5; d) for 75 previously open cases. Additionally, we show that n4(6; 14)=24, n4(7; 9)=18, and n4(7; 10)=20. Moreover, we classify optimal quaternary codes for some values of n and k. c © 2003 Elsevier B.V. All rights reserved.

Journal: :Acta Crystallographica Section E Structure Reports Online 2012

Journal: :Acta Crystallographica Section E Structure Reports Online 2011

Journal: :Acta Crystallographica Section E Structure Reports Online 2011

2017
Xiumin Wang Da Teng Ruoyu Mao Na Yang Ya Hao Jianhua Wang

A marine arenicin-3 derivative, N4, displayed potent antibacterial activity against Gram-negative bacteria, but its antibacterial mode of action remains elusive. The mechanism of action of N4 against pathogenic Escherichia coli was first researched by combined cytological and transcriptomic techniques in this study. The N4 peptide permeabilized the outer membrane within 1 min, disrupted the pla...

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