objective(s): to appraise the antihepatotoxic efficacy of ethanolic extract of operculum turpethum root on the liver of swiss albino mice.   materials and methods:   hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of n-nitrosodimethylamine (ndma) at the concentration of 10 mg/kg body weight. the liver toxicity and therapeutic effect of the plant et...

N-Nitrosodimethylamine is one of the main N-nitroso compound,commonly found in drinking water and is a potent hepatotoxin, carcinogen and mutagen. The curative effect of ethanolic root extract of Operculina turpethum was studied for its possible hepatoprotective potential against NNitrosodimethylamine in Swiss albino mice. Hepatic malondialdehyde (MDA), Superoxide dismutase(SOD),catalase(CAT),g...

In the Indian traditional system of medicine Operculina turpethum is commonly used to treat various ailments including peptic ulcer, inflammation, and pain. Ulcer preventive and ulcer protective activities of HAOP and MOP stem bark extracts of Operculina turpethum (100 mg/kg, b.w., orally) were evaluated employing aspirin + pylorus ligation (APL) model in experimental rats. The results suggeste...

  Objective(s): To appraise the antihepatotoxic efficacy of ethanolic extract of Operculum turpethum root on the liver of Swiss albino mice.   Materials and Methods:   Hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of N-nitrosodimethylamine (NDMA) at the concentration of 10 mg/kg body weight. The liver toxicity and therapeutic effect of the ...

The root extract of Operculina turpethum (OTE) has been used as an anti-inflammatory, purgative, and hepato-protective agent. N-Nitrosodimethylamine (NDMA) is a potent hepatotoxin that induces fibrosis of the liver. In the present study, we examined the therapeutic effects of OTE root extract against NDMA-induced hepatotoxicity and clastogenicity in rats. Hepatic fibrosis was induced in adult m...

OBJECTIVE(S) To appraise the antihepatotoxic efficacy of ethanolic extract of Operculum turpethum root on the liver of Swiss albino mice. MATERIALS AND METHODS Hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of N-nitrosodimethylamine (NDMA) at the concentration of 10 mg/kg body weight. The liver toxicity and therapeutic effect of the plant ethano...

Non-opioid analgesics including both selective and non-selective cyclooxygenase (COX) inhibitors and acetaminophen are the most widely used treatments for pain. Inhibition of COX is thought to be largely responsible for both the therapeutic and adverse effects of this class of drugs. So it is necessary to find some of the alternate effective measures. The root extract of Operculina turpethum ha...

The ethanolic extract obtained from roots of Operculina turpethum (Convolvulaceae) were evaluated for hepatoprotective activity in rats by inducing liver damage by paracetamol. The ethanol extract at an oral dose of 200 mg/kg exhibited a significant protective effect by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and total bili...

Trivrit (Operculina turpethum) was considered as Agra Dravya among Ayurvedic classics apart from Sukha Virechana Karma it has many therapeutic uses and is mentioned in treatment of Kusta, Kamala, Anaha, Visarpa, Grandhi etc. various Yogas (medicinal preparations) were classical books like Charaka Samhitha, Sushrutha Astanga Hridaya, Sarangadhara Nighantus got important chemical constituents res...

Vector control is the foremost step to diminish the mosquito borne diseases as the proper vaccinations are yet to develop against those obnoxious diseases. After many resistant cases, it is important to develop other sources of eco-friendly insecticides. The present piece of study was designed to evaluate the mosquito larvicidal efficacy of Operculina turpethum against malarial vector Anopheles...