Psychological stress contributes to increased susceptibility to a number of diseases including cancer. The present study was designed to assess the effect of chronic unpredictable stress on N-nitrosodiethylamine induced liver toxicity in terms of in vivo antioxidant status and DNA damage in Swiss albino mice. The animals used in this study were randomized into different groups based on the trea...

Hepatocyte growth factor (HGF) has been reported to have both positive and negative effects on carcinogenesis. Here, we show that the loss of c-Met signaling in hepatocytes enhanced rather than suppressed the early stages of chemical hepatocarcinogenesis. c-Met conditional knockout mice (c-metfl/fl, AlbCre+/-; MetLivKO) treated with N-nitrosodiethylamine developed significantly more and bigger ...

In this study, the activity of methanol extract of Prosopis cineraria (MPC) was evaluated in N-nitrosodiethylamine (DEN, 200mg/kg) induced experimental liver tumor in male Wistar rats. It was found that the administration of MPC (200 and 400mg/kg) effectively suppressed liver tumor induced by N-nitrosodiethylamine (DEN) as revealed by decrease in N-nitrosodiethylamine (DEN) induced elevated lev...

The chemopreventive effect of ethanol root extract of Indigofera aspalathoides was evaluated in N-nitrosodiethylamine-induced experimental liver tumor in mice. Pretreatment with ethanol root extract (100 mg/kg, p.o.) for three weeks significantly reduced the impact of N-nitrosodiethylamine toxicity (50 mg/kg, i.p.) on the serum markers of liver damage, aspartate aminotransferase, alanine aminot...

Naturally occurring plant products belonging to different chemical classes namely alizari n, an anthraquinone, caffeine, a methyl xanthine derivative and quercetin, a flavonol were studied for their effect on elimination of metabolites of [14C]_N_ nitrosodiethylamine e4C-NDEA) through respiration in mice. Treatment with caffeine, quercetin and alizarin at doses of 200, 9 and 9 JLg/ml respective...

Nitrosamines, mainly N-nitrosodimethylamine (NDMA), N-nitrosomethylethylamine (NMEA) and N-nitrosodiethylamine (NDEA) are highly mutagenic compounds that are suspected of carcinogenic activity to the human body. The aim of the paper is the evaluation of the possibility of N-nitrosomethylethylamine and N-nitrosodiethylamine formation as a result of the reaction of methylethylamine (MEA) or dieth...

this study was designed to explore the protective effects of abrus precatorius l. (leguminosae) (ap) in hepg2 cells and n-nitrosodiethylamine (ndea) induced hepatocellular carcinoma in swiss albino rats. the effects of aqueous/ethanolic (50%) extract of ap on hepatic markers, haematological and histopathological parameters, and antioxidant enzymes were evaluated in ndea (200 mg/kg and ccl4, 3 m...