نتایج جستجو برای: Myricitrin

تعداد نتایج: 90  

2017
Shimei Qi Zunyong Feng Qiang Li Zhilin Qi Yao Zhang

Myricitrin, a naturally occurring polyphenol hydroxy flavonoid, has been reported to possess anti-inflammatory properties. However, the precise molecular mechanism of myricitrin's effects on LPS-induced inflammation is unclear. In the present study, myricitrin significantly alleviated acute lung injury in mice. Myricitrin also markedly suppressed the production of NO, TNF-α, IL-6, and MCP-1 in ...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Flavia Carla Meotti Ana Paula Luiz Moacir Geraldo Pizzolatti Cândida A L Kassuya João B Calixto Adair R S Santos

The present study investigated the antinociceptive effects of the flavonoid myricitrin in chemical behavioral models of pain in mice and rats. Myricitrin given by i.p. or p.o. routes produced dose-related antinociception when assessed on acetic acid-induced visceral pain in mice. In addition, the i.p. administration of myricitrin exhibited significant inhibition of the neurogenic pain induced b...

Journal: :Neuroscience Letters 2011
Marina Machado Córdova Maria Fernanda de Paula Werner Morgana Duarte da Silva Ana Paula Ruani Moacir Geraldo Pizzolatti Adair R.S. Santos

The present work explored the antinociceptive effects of the flavonoid myricitrin in models of overt nociception triggered by intraplantar injection of chemical algogens into the hind paw of mice. The nociception induced by bradykinin (3 nmol/paw i.pl.) was abolished by prior treatment with myricitrin (10-100mg/kg, i.p.) with ID(50) of 12.4 (8.5-18.1)mg/kg. In sharp contrast, myricitrin failed ...

Journal: :Bioscience, biotechnology, and biochemistry 2005
Atsushi Yokomizo Masamitsu Moriwaki

Myricitrin permeated the human intestinal Caco-2 cell monolayer via the paracellular pathway in a time- and concentration-dependent manner. Myricitrin was not conjugated by Caco-2 cells. Myricitrin was degraded by simulated intestinal digestion, but permeability did not change significantly.

Journal: :Molecules 2016
Bin Zhang Yaping Chen Qiang Shen Guiyan Liu Jingxue Ye Guibo Sun Xiaobo Sun

Hyperglycemia, as well as diabetes mellitus, has been shown to trigger cardiac cell apoptosis. We have previously demonstrated that myricitrin prevents endothelial cell apoptosis. However, whether myricitrin can attenuate H9c2 cell apoptosis remains unknown. In this study, we established an experiment model in H9c2 cells exposed to high glucose. We tested the hypothesis that myricitrin may inhi...

Journal: :Progress in Neuro-Psychopharmacology and Biological Psychiatry 2011
M. Pereira I. P. Siba L. R. Chioca D. Correia M.A.B.F. Vital M. G. Pizzolatti A.R.S. Santos R. Andreatini

Myricitrin is a nitric oxide (NO) and protein kinase C (PKC) inhibitor that has central nervous system activity, including anxiolytic-like action. Nitric oxide inhibitors blocked the behavioral effects of apomorphine, suggesting an antipsychotic-like effect. Furthermore, PKC inhibition reduced psychotic symptoms in acute mania patients and blocked amphetamine-induced hyperlocomotion, suggesting...

Journal: :International journal of clinical and experimental medicine 2015
Jie Li Mei Zhang Juanjuan Ma

Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) and the stimulation of platelet-derived growth factor (PDGF)-BB play major pathological processes involved in the development of cardiovascular diseases. As a result, the use of anti-proliferative and anti-migratory agents for VSMCs offers promise for the treatment of vascular disorders. Myricitrin is a naturally occur...

2016
Jing Sun Guibo Sun Xiaolan Cui Xiangbao Meng Meng Qin Xiaobo Sun

Doxorubicin (Dox) is one of the most effective and widely used anthracycline antineoplastic antibiotics. Unfortunately, the use of Dox is limited by its cumulative and dose-dependent cardiac toxicity. Myricitrin, a natural flavonoid which is isolated from the ground bark of Myrica rubra, has recently been found to have a strong antioxidative effect. This study aimed to evaluate the possible pro...

2013
Wei Chen Lina Feng Yang Shen Hongming Su Ya Li Jingjing Zhuang Lingxia Zhang Xiaodong Zheng

Oxidative stress was thought to be associated with acrylamide cytotoxicity, but the link between oxidative stress and acrylamide cytotoxicity in the gastrointestinal tract, the primary organ in contact with dietary acrylamide, is still unclear. This study was conducted to evaluate the antioxidant activity of natural dietary compound myricitrin and its protective role against acrylamide cytotoxi...

2017
Min Wang Gui-bo Sun Yu-yang Du Yu Tian Ping Liao Xue-song Liu Jing-xue Ye Xiao-bo Sun

Modulation of oxidative stress is therapeutically effective in ischemia/reperfusion (I/R) injury. Myricitrin, a naturally occurring phenolic compound, is a potent antioxidant. However, little is known about its effect on I/R injury to cardiac myocytes. The present study was performed to investigate the potential protective effect of myricitrin against hypoxia/reoxygenation (H/R)-induced H9c2 ca...

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