We report the observation of a high neutrophil myeloperoxidase activity (MPXI) in patients with megaloblastic anemia. MPXI is rapidly measured as part of an automated complete blood count (Technicon H*1, Technicon Instruments Corp, Tarrytown NY). We describe the range of MPXI levels in healthy and patient populations and in 10 cases of megaloblastic anemia, including five having elevated mean c...

Genetic abnormalities often serve as the catalyst to stimulate critical insights into normal biology. In many cases, examining such experiments of Nature explicates not only the abnormal but also serves to illustrate underlying normal principles. Within the context of myeloperoxidase biosynthesis, we have examined the impact of specific missense mutations that cause inherited myeloperoxidase de...

the adipokines, leptin and adiponectin, have a prominent role in the pathogenesis of coronary artery disease (cad). the inflammatory enzyme, myeloperoxidase (mpo) also has an important role in the pathogenesis of cad. association of the adipokines with mpo remains to be resolved in patients with cad. in this case-control study, 100 patients with cad and 100 control subjects were appropriately r...

background: polymorphisms in the immune related genes are important in the clinical outcome of helicobacter pylori infection. myeloperoxidase -463 g/a polymorphism has been shown to reduce enzyme expression and activity. objective: the aim of the present study is to investigate the association of myeloperoxidase g-463a polymor-phism with clinical outcome of helicobacter pylori infection. method...

repeated bone marrow examination was found to be of value in assessing response to treatment in megaloblastic anemia. the objective of this study was monitoring the response of megaloblastics to treatment, concerning the location of neutrophilic myeloperoxidase and myeloperoxidase index (mpxi) and their variation in megaloblastic erythroid progeny. it is possible to follow up megaloblastic case...

Background: Polymorphisms in the immune related genes are important in the clinical outcome of Helicobacter pylori infection. Myeloperoxidase -463 G/A polymorphism has been shown to reduce enzyme expression and activity. Objective: the aim of the present study is to investigate the association of myeloperoxidase G-463A polymor-phism with clinical outcome of Helicobacter pylori infection. Method...

The objective : to assess changes in the level of lactoferrin and ferritin patients with pulmonary tuberculosis COVID-19 during treatment, determine their correlation parameters free radical oxidation antioxidant protection. Subjects methods . Levels erythrocyte catalase ferritin, neutrophil myeloperoxidase were studied against background successful treatment group (n = 80) 75). Their protectio...

dendritic cells function as the main cellular population responsible for professional antigen presentation and hence for induction of primary immune responses. although they are present in virtually every tissue, nevertheless their number is usually so low that it makes their isolation for studies very difficult. in this study, we purified dendritic cells from mouse spleen by a three-step enric...

background: neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (sci) and these cells cause substantial secondary tissue damage. the purpose of this study was to determine the effect of oleuropein (oe) on myeloperoxidase (mpo) activity as an index of neutrophil infiltration. methods: rats were randomly divided into four groups of 7 rats each as...