background: solid tumors may occur in 3% of the patients with chronic myeloid leukemia (cml). in this paper, we presented a case of cml following treatment of colon cancer. case presentation: a 25 year old man was diagnosed of adenocarcinoma of rectosigmoid treated with fluorouracil-based chemotherapy. following relapse, he received florouracil, oxaliplatin and irinotecan during the next year. ...

with the present specifications for clasification, 95% of chronic myelogeneous leukaemia (cml) cases have the t(9;22), which brings the abl oncogene to the bcr region and results in a hybrid gene bcr/abl. there may be involvement of other chromosomes in 2-10%, and secondry or additional chromosome abberations may present in 60-80% during the progression of the disease. in the majority of the re...

in this article, a mathematical model describing the growth orterminating myelogenous leukemia blood cancer's cells against naive t-celland eective t-cell population of body, presented by fractional dierentialequations. we use this model to analyze the stability of the dynamics, whichoccur in the local interaction of eector-immune cell and tumor cells. wewill also investigate the optima...

Objective: Proteasomal system is the primary protein degradation mechanism and important for cellular homeostasis. On other hand, increased proteasome activity protects cancer cells from cell death. The objective of this preliminary study was to determine response proteasomal oxidative stress in human lines including K562 chronic myelogenous leukemia, U251 glioblastoma, DU145 prostate cancer, H...

Although chronic myelogenous leukemia in pregnancy is rare, its management and treatment is more difficult and complicated.Treatment of patients with chronic myelogenous leukemia includes bone marrow transplantation, however in less than 30% of patients the donor’s organ would be accepted. To this end, cytotoxic therapy is considered as an alternative therapeutic option. This option provides sa...

An expanded cohort study of 74,828 benzene-exposed and 35,805 unexposed workers were followed during 1972 to 1987, based on a previous study in 12 cities in China. A small increase was observed in total cancer mortality among benzene-exposed compared with unexposed workers (relative risk [RR] = 1.2). Statistically significant excesses were noted for leukemia (RR = 2.3), malignant lymphoma (RR =...

Background : Acute myelogenous leukemia is a cancer that affects myeloid cells. Several complications occur due to acute myelogenous leukemia of which is granulocytic sarcoma. This case report discusses the analysis of skin abnormalities in an acute myelogenous leukemia patient. Case description : Skin examination and fine needle aspiration of the nodules in comparison with previous bone marrow...

Background:Leukemia is cancer of blood and bone marrow cells. In general, there are four types of leukemia: chronic myelogenous leukemia (CML), acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL).  Fractal geometry can be introduced as one of the effective ways to detect this type of cancer. In this study, with introduc...

Background: Abnormal regulation of genes has been closely related to gastric cancer. The characterization cancer necessitated the development new therapeutics as well identification prognostic markers predict response novel drugs. In our study, we used RNA sequencing analyses show that on tissues markers. We specifically chose study RNF43 because it inhibits cancer-related Wnt/β-catenin signali...

Further investigations on phytochemical constituents of dichloromethane extract fromroots of Salvia lachnocalyx (S. lachnocalyx) led to the isolation and identification of eightknown diterpenoids from this plant for the first time. The chemical structures of the purifiedcompounds were elucidated using spectroscopic analyses including EI-MS, 1H and 13C NMR andby compariso...