mass vaccination against viral infections such as mumps is a very noticeable and appropriate attempt in common health. mumps infection has severe complications like deafness, infertility and meningitis. attenuated live vaccine of mumps is produced and used to prevent the problems. viral content in the monovalent vaccine is assayed with different methods. nowadays international standards introdu...

  Mass vaccination against viral infections such as mumps is a very noticeable and appropriate attempt in common health. Mumps infection has severe complications like deafness, infertility and meningitis. Attenuated live vaccine of mumps is produced and used to prevent the problems. Viral content in the monovalent vaccine is assayed with different methods. Nowadays international standards intro...

vaccination against mumps is included in world health organization (who) program of global immunization. safety and efficacy of vaccines must be confirmed by control units in charge of public health. in iran, the secondary control on potency of vaccine has not been set up yet. we decided to overcome this problem by developing who and nibsc methods in food and drug control lab. ‎nine dilutions o...

stability studies play a critical role in assuring product quality at all points in the vaccine life cycle. these studies used to determine vaccine expiry date and vaccine efficacy. accelerated stability and long term stability study performed for three batches of trivalent oral poliomyelitis vaccine (opv) and three batches of monovalent opv (type1) manufactured by razi institute. after samplin...

background: potency test for control of rubella vaccine is a significant factor to qualify production line and vaccination pro­gram. for this reason, who recommends to use the microtitration method by both vaccine companies and control laborato­ries. then the study was done to improve this test. methods: three rubella virus samples, including an in-house standard, a lot of vaccine and an in- pr...

background whooping cough is caused by bordetella pertussis, and it remains a public health concern. whole-cell pertussis vaccines have been commonly employed for expanded immunization. there is no doubt of the efficacy of whole cell pertussis vaccine, but it is necessary to improve the vaccine to decrease its toxicity. objectives in this study, an inactivation process of dealing with pertussis...

poliomyelitis, an acute viral infectious disease caused by poliovirus, still remains a public health problem in developing countries. despite the global effort to eradicate polio, continuing the polio immunization with a potent and safe vaccine is essential. for accurate vaccine evaluation, three types of cell lines including hela, hep2c and vero were evaluated and compared using two methods of...

a micro neutralization test was used for the detection and evaluation of mumps neutralizing antibodies. a total of 1037 blood samples from selected groups of students aged 7 to 22 years in south and east of tehran, 139 blood samples from the umbilical cords of pregnant women at two tehran hospitals at delivery time, and 190 samples from children under five years of age who were living in two vi...

Wild type mumps viruses are highly neurotropic and a frequent cause of aseptic meningitis in unvaccinated humans. To test whether attenuated mumps viruses used in the manufacture of mumps vaccines have neurovirulent properties, a monkey neurovirulence safety test (MNVT) is performed. However, results with several mumps virus MNVTs have raised questions as to whether the test can reliably discri...

discussion pcr or enzyme linked immunosorbent assay (elisa) on serum or cerebrospinal fluid would be the inevitable basis for accurate diagnosis in such cases. case presentation we reviewed three patients diagnosed with aseptic meningitis due to acute non-mumps associated parotitis based on clinical and laboratory findings. while there are many similarities between the clinical characteristics ...