Introduction: Minocycline has anti-inflammatory, anti-apoptotic, and anti-oxidant effects. Preclinical data suggest that minocycline could be beneficial for treating common neurological disorders, including Parkinson disease and multiple sclerosis. Methods: In this study, the effects of minocycline on harmaline-induced motor and cognitive impairments were studied in male Wistar rats. The rats ...

UNLABELLED Falling has been identified as a major complication in persons who have had a stroke. The purpose of this study was to investigate the effect of accumulated impairments on the risk of falling in community-dwelling stroke survivors. METHODS Community-dwelling stroke survivors were identified from the Kansas City Stroke Study, a large cohort study of stroke survivors. We evaluated th...

BACKGROUND AND PURPOSE Transient ischemic attack (TIA) increases the risk for a subsequent stroke. Typical symptoms include motor weakness, gait disturbance, and loss of coordination. The association between the presence of motor impairments during a TIA and the chances of a subsequent stroke has not been examined. In the current meta-analysis, we examine whether the odds of a stroke are greate...

INTRODUCTION we have tested the hypothesis that the co-occurrence of common impairments (motor and cognitive impairments, vision and hearing loss, depressive symptoms) of later life have exacerbating effects on disability [activities and instrumental activities of daily living, social and role function, (in)activity]. METHOD data were drawn from a community-based sample of 624 people aged 57 ...

objective(s):neurotoxicity of anticancer drugs complicates treatment of cancer patients. vinblastine (vbl) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen. materials and methods: the effects of vbl treatment on motor, learning and memory functions of male and female wistar rats were studied by behavioral related tests. animals were given chro...

OBJECTIVE We investigated the co-occurrence of motor impairments in children with speech and language impairments. METHOD Three search strategies produced 16 studies that met the inclusion criteria for the meta-analysis. These 16 studies yielded 110 effect sizes (d). Heterogeneity was evaluated by obtaining Q and I-squared values. RESULTS Children with speech and language impairments made m...

Although eye-based interactions can be beneficial for people with motor impairments, they often rely on clunky or specialized equipment (e.g., stationary eye-trackers) and focus primarily gaze blinks. However, two eyelids open close in different orders duration to form rich eyelid gestures. We take a first step design, detect, evaluate set of gestures impairments mobile devices. present an algo...