نتایج جستجو برای: Mono-iodoacetate

تعداد نتایج: 19952  

Curcumin has been found to be very efficacious against many different types of diseases. However, the major disadvantage associated with the use of curcumin is its low systemic bioavailability. In the present study the protective effects of curcumin-loaded poly lactic-co-glycolic acid nanoparticles (nanocurcumin) against mono-iodoacetate-induced osteoarthritis in rats was inves...

2017
Ryusuke Saito Takeshi Muneta Nobutake Ozeki Yusuke Nakagawa Mio Udo Katsuaki Yanagisawa Kunikazu Tsuji Makoto Tomita Hideyuki Koga Ichiro Sekiya

BACKGROUND It is still debated whether strenuous running in the inflammatory phase produces beneficial or harmful effect in rat knees. We examined (1) the dropout rate of rats during a 30-km running protocol, (2) influences of strenuous running and/or low amounts of mono-iodoacetate injection on cartilage, and (3) the effect of strenuous running on synovitis. METHODS Rats were forced to run 3...

2017
Firoozeh Niazvand Layasadat Khorsandi Mohammadreza Abbaspour Mahmoud Orazizadeh Negar Varaa Mahtab Maghzi Kheironesa Ahmadi

Curcumin has been found to be very efficacious against many different types of diseases. However, the major disadvantage associated with the use of curcumin is its low systemic bioavailability. In the present study the protective effects of curcumin-loaded poly lactic-co-glycolic acid nanoparticles (nanocurcumin) against mono-iodoacetate-induced osteoarthritis in rats was investigated. Mono-iod...

2017
Előd Nagy Enikő Vajda Camil Vari Sándor Sipka Ana-Maria Fárr Emőke Horváth

OBJECTIVE This study aimed to quantify the cartilage- and subchondral bone-related effects of low-dose and high-dose meloxicam treatment in the late phase of mono-iodoacetate-induced osteoarthritis of the stifle. METHODS Thirty-four male Wistar rats received intra-articular injection of mono-iodoacetate to trigger osteoarthritis; 10 control animals (Grp Co) received saline. The mono-iodoaceta...

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