multiple sclerosis (ms) is an autoimmune disease in which auto-reactive t cells react with self-antigens expressed in the central nervous system (cns). the main cause of ms is unknown. nonetheless, the most probable theory is based on molecular mimicry, which suggests that some infections can activate t cells against brain auto-antigens like myelin proteolipid protein (plp) and initiate the dis...

conclusions molecular assays in the early stages of the disease could help in elucidating the effectiveness of the mbp as a prognostic factor in ms. methods this study is convergence of three arms including in silico and in vitro (bioinformatics) with the in vivo (experimental). a novel methodology combining molecular techniques was used to confirm the antigenic properties of mbp and study its ...

EditoriAL EditoriAL Over the course of evolution, microorganisms have developed innovative survival strategies to thrive in their hosts. 1 The human body is home to many species of bacteria, viruses, fungi, and other invertebrate parasites. Some of these organisms that live and thrive in humans are com-mensals and are harmless. They may be also beneficial to the host as they provide certain nut...

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Papilio swallowtail butterflies exhibit a remarkable diversity of Batesian mimicry, manifested in several sex-limited and polymorphic types. There is little understanding of how this diversity is distributed within Papilio, and how different mimicry types have evolved in relation to each other. To answer these questions, I present a graphical model that connects various mimicry types by hypothe...

Molecular mimicry is fundamental to biology and transcends to many disciplines ranging from immune pathology to drug design. Structural characterization of molecular partners has provided insight into the origins and relative importance of complementarity in mimicry. Chemical complementarity is easy to understand; amino acid sequence similarity between peptides, for example, can lead to cross-r...