We analyzed the apoptosis and anti-tumour activities of several Mn(III)-salen and -salphen complexes (1-14) towards three different cultured human cancer and non-cancer cells. We demonstrated that most of the Mn(III)-salen and -salphen complexes affect cell viability and induce apoptosis in MCF7 cells. Biochemically active Mn(III)-salen and -salphen complexes induced nuclear fragmentation and r...

antioxidants act as free radical scavengers in the oxidation processes. thus, they will certainly play diverse roles in the biological systems and the therapy of a wide variety of diseases. regarding this fact, in the present study, we synthesized two new salen ligand compounds by the condensation of ethylendiamine and salicylaldehyde derivatives in excellent yields.the structures of these liga...

Enantiomerically pure secondary alcohols are essential compounds in organic synthesis and are used as chiral auxiliaries and synthetic intermediates in the pharmaceutical, agrochemical, and fine chemical industries. One of the attractive and practical approaches to achieving optically pure secondary alcohols is oxidative kinetic resolution of racemic secondary alcohols using chiral Mn(III) sale...

By the reaction of chiral Mn(III) Schiff-base complexes with the dicyanoruthenate building block, [Ru(salen)(CN)2](-) (salen(2-) = N,N'-ethylenebis(salicylideneimine) dianion), two couples of enantiomerically pure chiral cyano-bridged heterobimetallic one-dimensional (1D) chain complexes, [Mn((R,R)-salcy)Ru(salen)(CN)2]n (1-(RR)) and [Mn((S,S)-salcy)Ru(salen)(CN)2]n (1-(SS)) (Salcy = N,N'-(1,2-...

Immobilization of the chiral salen-metal complex [Mn(III)(salen)(H(2)O)(2)ClO(4)] on the Keggin-type polyoxometalate (POM) skeletons leads to the isolation of POM derivatives functionalized with chiral salen-metal complexes, which represent the first examples of introducing chiral salen-metal complexes into the POM systems.

A pioneering research on a self-assembly of the magneto-anisotropic module [Re(CN)7] with the Mn(III) complexes involving Salen type (N,N′-ethylenebis(salicylideneiminate)) Schiff base (SB) ligands was performed using the known [Mn(Salen)(H2O)2]2(ClO4)2·H2O (1) and the firstly synthesized [Mn2(Salen)2OAc]PF6 (2). In the case of 1, a slow diffusion of the component solutions led to the ionic com...

Synthetic methods to prepare organometallic and coordination compounds such as Schiff-base complexes are diverse, with the route chosen being dependent upon many factors such as metal-ligand combination and metal oxidation state. In this work we have shown that electrochemical methodology can be employed to synthesize a variety of metal-salen/salan complexes which comprise diverse metal-ligand ...

Two hydroxo-bridged complexes, {[Mn(III)(3-CH(3)O)salen](2)[Cr(III)(salen)(OH)(2)]}ClO(4)·6H(2)O (1) and {[Mn(III)(5-CH(3))salen](2)(OH)}ClO(4)·3H(2)O (2) [salen = N,N'-ethylenebis(salicylideneiminato) dianion], have been synthesized by the hydrolysis of the corresponding Mn(III)(Schiff-Bases) derivatives and [Cr(salen)(H(2)O)(2)]Cl precursors. X-Ray structure characterization reveals the discr...

This study deals with the synthesis and evaluation of salen based derivatives as fire retardants in thermoplastic polyurethane. Salens, hydroxysalens and their first row transition metal complexes (salen-M) were synthesized (Copper, Manganese, Nickel and Zinc). They were then incorporated in thermoplastic polyurethane (TPU) with a loading as low as 10:1 weight ratio. The thermal stability as we...

Salen Mn complexes, including EUK-134, EUK-189 and a cyclized analog EUK-207, are synthetic superoxide dismutase (SOD) and catalase mimetics that are beneficial in many models of oxidative stress. Though not designed to target the mitochondria, salen Mn complexes show "mito-protective" activity, that is, an ability to attenuate mitochondrial injury, in various experimental systems. Treatment wi...