Objective Background: 2% to 6% of vasectomized men will ultimately seek vasectomy reversal and late stricture and obstruction after operation are relatively common. Objective: To find a method for improving of vasovasostomy outcomes, we used intra-operative local mitomycin-C to prevent possible fibrosis and stricture. MaterialsAndMethods Design, setting, and participants: 44 patients in our ref...

Objective (s): This study aimed at investigation of preparation and stability study of Mitomycin and Mitomycin loaded nanoliposems and efficacy of the combination of Mitomycin -loaded nanoliposomes and Curcumin versus Mitomycin in suppressing HTB-9 and L929 cell lines, in vitro.Materials and Methods: An HPLC method was validated based on Q2 (R1) International Conference on Harmonization (ICH) g...

Introduction: Since the days of Hippocrates, many modifications have been proposed in endonasal dacrocystorhinostomy (DCR), with the use of new drugs and implants showing variable results. The objective of this study was to analyze whether the use of silicon tubing or mitomycin C administration has an added advantage over conventional endonasal DCR.  Materials and Methods: A randomized controll...

Studies made of the treatment with 66 courses of mitomycin C in 28 patients with chronic myelogenous leukemia are reported. The effect of mitomycin C was investigated according to the relation between drug and host factors, comparison with the effects of other agents, and drug resistance. Patients with less hematological and clinical symptoms responded better to mitomycin C therapy. The remissi...

purpose: to compare the efficacy and safety of topical mitomycin- c 0.01% versus dexamethazone phosphate 0.1% in patients with refractory vernal keratoconjunctivitis (vkc). methods: in this double blind randomized clinical trial, patients with refractory vkc were randomly assigned to treatment with topical mitomycin-c 0.01% eye drops (n=27) or dexamethazone phosphate 0.1% (n=27), four times dai...

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AIM To investigate the effect of trabeculectomy with and without mitomycin C in post-keratoplasty glaucoma. METHODS A retrospective study was performed on patients who underwent trabeculectomy for glaucoma after penetrating keratoplasty. 34 eyes of 32 patients were included in this study. 26 eyes received trabeculectomy with mitomycin C and eight eyes without mitomycin C. The procedure was de...

Mitomycin C reduced with sodium borohydride Induced the DNA damage at deoxyguanosines preferentially in dinucleotide sequence G-T. The DNA damage produced strand breaks when subsequently heated. The DNA damage scarcely occurred when the end-labeled DNA was preincubated with ethidium brotmde or actinomycin D before the addition of mitomydn C and the reducing agent. Fully reduced mitomycin C did ...