pioglitazone (pg) is one of thiazolidinediones used for the treatment of type ii diabetes mellitus. some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. in the present study, the protective effect of some atp suppliers are investigated against mitochondrial toxicity of pg in isolated rat mitochondria. mitochondrial viability was investigated by mt...

prohibitins are chaperone proteins highly conserved among eukaryotes. many different functions have been attributed to prohibitins depending on their tissue expression and sub-cellular localization. prohibitins play a major role in mitochondrial physiology, regulating the stability and the processing of both respiratory chain complex subunits and opa1, a mitochondrial fusion regulating protein....

previous studies demonstrated that cse induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of cse in human health and disease. the present study was carried out to further characterize and compare toxic effect of cse extract on isolated mitochondria obtained from either a directly contacting tissue (i...

maternal smoking has been recognized as a common cause of low birth weight, preterm birth and the decrease of gestational age period. unfortunately, there is an increasing interest within public especially woman in iran in the tobacco products consumption. on the other hand, the deleterious effect of maternal smoking on human fetus in pregnancy period especially in the first trimester encourage...

Background: Although the bio kinetics, metabolism and chemical toxicity of Atorvastatin are well known, until recently little attention was paid to the potential neurotoxic effect of Atorvastatin (Atv). Regarding the concrete evidences indicating Atv may reduce Coenzyme Q10 (CoQ10) levels through blockage of  metalonate cycle, the present work aims to determine if Atorvastatin may provide toxic...

edaravone, an antioxidant and radical scavenger, showed protective effects against oxidative stress-like condition. paraquat (pq) is a toxic herbicide considerable evidence suggests that oxidative stress and mitochondrial dysfunction contribute to pq toxicity. in this study, protective effect of edaravone against pq induced toxicity and reactive oxygen species (ros) generation in a549 cells and...

Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...

Edaravone, an antioxidant and radical scavenger, showed protective effects against oxidative stress-like condition. Paraquat (PQ) is a toxic herbicide considerable evidence suggests that oxidative stress and mitochondrial dysfunction contribute to PQ toxicity. In this study, protective effect of edaravone against PQ induced toxicity and reactive oxygen species (ROS) generation in A549 cells and...