introduction and objective: zinc as the second trace element of the human body plays an important role in numerous functions. a large number of research studies have showed serum zinc deficiency and excess urinary excretion in patients with major beta thalassemia, but few studies revealed excess urinary zinc excretion in minor beta thalassemia and no study investigated serum zinc levels in this...

background: hb a2 is elevated in subjects with beta thalassemia minor but small percent of carriers have normal hb a2 with elevated levels of hbf (2-10%). this type of thalassemia is called delta beta thalassemia, and can be missed in pre-marriage hematologic consults or screening which leads to increased risk of child birth with beta thalassemia major. materials and methods: in this prospectiv...

Increased HbA2 is a characteristic finding in minor beta thalassemia. Minor β-thalassemia is a heterozygote form of β-thalassemia that carries thalassemia genes but does not cause thalassemia disease. Diagnosis of carriers is done by CBC, RBC Index, and HbA2 test. Very few cases of people with minorthalassemia have a normal HbA2. According to the results of this pilot study it seams that percen...

introduction: the current study evaluated the value of red blood cell (rbc) indices and the corresponding cut- off points for β-thalassemia control programs in iran. materials and methods: 1,150 individuals (575 couples) with low rbc indices and normal hemoglobin a2 who had been referred to the genetic centre of isfahan, were tested during pre-marital screening analyses, in the 2 year period, 2...

OBJECTIVE Anti-apoptotic proteins such as Bcl-2 and Bcl-xL may play a role in the survival of erythroid progenitor cells. Information about these proteins in patients with β-thalassemia minor is limited. We aimed to determine the levels of serum Bcl-2 in patients with β-thalassemia minor. MATERIALS AND METHODS Ninety-seven patients (60 females and 37 males with mean age of 29±21 years) with β...

The most common hypochrom microcytic anemia are iron deficiency anemia (IDA) and thalassemia minor (TM). The results of some studies have shown that IDA can cause misdiagnosis of heterozygote β-thalassemia due to decrease in HbA2 level. Our aim in this study was evaluating the effect of IDA on HbA2 levels; Furthermore hematolagic values in CBC of these two diseases will be compared. In this stu...

Background: Until now, no study has been reported investigating the association between β-thalassemia minor and Helicobacter pylori (H. pylori) infection. This study was designed to compare H. pylori infection rate between β-thalassemia minor patients and healthy controls. Methods: A number of 100 β-thalassemia minor patients (50 males, 50 females) and 100 gender-matched healthy...

OBJECTIVE Growth retardation in children with b-thalassemia major is multifactorial. Some etiologies described for this condition are hemochromatosis, disturbed growth hormone (GH) / insulin growth factor-1 (IGF-1) axis, undernutrition and hypermetabolism. It has also been proven that growth retardation is present in b-thalassemia major children despite regular transfusion and chelation. Our ai...