Our understanding of how chromatin structure influences cellular processes such as transcription and replication has been limited by a lack of nucleosome-positioning data in human cells. We describe a high-resolution microarray approach combined with an analysis algorithm to examine nucleosome positioning in 3,692 promoters within seven human cell lines. Unlike unexpressed genes without transcr...

Abbreviations: UV-R: UV Radiation; SCF: Stem Cell Factors; FGF2: Fibroblast Growth Factor; PAH: Phenylalanine Hydroxylase; TH1: Tyrosinase Hydroxylase 1; TRP-2: DOPA-Chrome Tautomerase; TRP-1: DHICA Oxidase; DHI: 5,6-Dihydroxyindole; DHICA: 5;6-Dihydroxyindole-2-Carboxylic Acid; Indole-5;6-Quinone I-Q; I-QCA: Indole-5,6-Quinone Carboxylic Acid; MSH: MelanocyteStimulating Hormone; TYR: Tyrosinas...

Nepeta (Lamiaceae) is an important genus with beneficial medicinal properties. N. sintenisiiBornm. has been used in folk medicine of Iran to cure various diseases. We investigated theanti-melanogenesis effects of n-hexane, MeOH, CH2Cl2, n-BuOH, EtOAc, and H2O extractsisolated from the plant in B16 melanoma cells. Various assays including cytotoxicity, mushroomtyrosinase inhibition, inhibition o...

main transcription factors, Sox10 and Mifta (microphthalmiaassociated transcription factor), are already known to be involved in this process [Dutton et al., 2001; Elworthy et al., 2003]. Fate specification of melanocytes depends upon Sox10, and on Wnt signalling, to mediate regulation of Mitfa transcription. In contrast, the precise mechanism resulting in stable melanocyte differentiation rema...

main transcription factors, Sox10 and Mifta (microphthalmiaassociated transcription factor), are already known to be involved in this process [Dutton et al., 2001; Elworthy et al., 2003]. Fate specification of melanocytes depends upon Sox10, and on Wnt signalling, to mediate regulation of Mitfa transcription. In contrast, the precise mechanism resulting in stable melanocyte differentiation rema...

main transcription factors, Sox10 and Mifta (microphthalmiaassociated transcription factor), are already known to be involved in this process [Dutton et al., 2001; Elworthy et al., 2003]. Fate specification of melanocytes depends upon Sox10, and on Wnt signalling, to mediate regulation of Mitfa transcription. In contrast, the precise mechanism resulting in stable melanocyte differentiation rema...

Nepeta (Lamiaceae) is an important genus with beneficial medicinal properties. N. sintenisiiBornm. has been used in folk medicine of Iran to cure various diseases. We investigated theanti-melanogenesis effects of n-hexane, MeOH, CH2Cl2, n-BuOH, EtOAc, and H2O extractsisolated from the plant in B16 melanoma cells. Various assays including cytotoxicity, mushroomtyrosinase inhibition, inhibition o...

We investigated the in vitro effects of p-coumaric acid on melanogenesis. The melanin content in B16F1 cells stimulated with p-coumaric acid significantly decreased (68 % vs. control) through inhibition of tyrosinase enzyme activity assessed using both cell-free and cellbased assays (46 and 27 % compared with control, respectively). In addition, stimulating B16F1 cells with p-coumaric acid redu...

adult neurogenesis is a process of producing nerve cells from their progenitor that occurs in some areas in the brain such as the hypothalamus. low activity in this area plays a role in neural degeneration and diseases such as multiple sclerosis, epilepsy and depression. ms is a neurodegenerative disease with a permanent disability that the main reason for it is axonal degeneration and neuronal...

background: pomegranate fruit (punica granatum l.) is a rich source of anthocyanin pigments resulting in vibrant colours and anti-oxidant contents. although the intensity and pattern of anthocyanin biosynthesis in fruit are strongly influenced by r2r3-myb transcription factors, little is known about the regulation and role of myb in anthocyanin pathway of pomegranate.objectives: the present stu...