نتایج جستجو برای: Micronuclei

تعداد نتایج: 2081  

Journal: :Molecular Cell 2021

Summary Micronuclei are aberrant nuclear compartments that can form as a result of chromosome mis-segregation. Frequent loss micronuclear envelope integrity exposes DNA to the cytoplasm, leading fragmentation and immune activation. Here, we use micronuclei purification show endoplasmic reticulum (ER)-associated nuclease TREX1 inhibits cGAS activation at by degrading upon rupture. We de...

K. L. Bairy, S. Benjamin, S.D. Manjula,

The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12mg/kg Endosulfan orally (10 pups/group),for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9mg/kg and 12mg/kg was administered along with vitamin C (20mg/kg). ...

2010
Koh-ichi Utani Yuka Kohno Atsushi Okamoto Noriaki Shimizu

The presence of micronuclei in mammalian cells is related to several mutagenetic stresses. In order to understand how micronuclei emerge, behave in cells, and affect cell fate, we performed extensive time-lapse microscopy of HeLa H2B-GFP cells in the presence of hydroxyurea at low concentration. Micronuclei formed after mitosis from lagging chromatids or chromatin bridges between anaphase chrom...

2011
Cosmin Teodor Mihai Gabriela Capraru Elena Truta Pincu Rotinberg Daniela Gherghel

The treatment of HeLa neoplastic cells with low frequency and intensity electromagnetic field has determined modifications of the micronuclei number, this impact being correlated with the application manner of the electromagnetic field (continuous or discontinuous). Thus, the continuous electromagnetic field has reduced the frequency of the micronuclei formation (2.91 ± 0.015 ‰), as compared to...

Journal: :Mutagenesis 1994
H Stopper I Eckert D Schiffmann D L Spencer W J Caspary

This study was designed to investigate a previously unidentified potential mechanism for mutation induction as well as to clarify a biological consequence of micronuclei with mutation induction as measured by trifluorothymidine (TFT) resistance in mouse L5178Y cells using four aneugens: colcemid, diethylstilbestrol, griseofulvin and vinblastine. All four compounds induced micronuclei which appe...

Journal: :Mutagenesis 1997
I Eckert W J Caspary M Nüsse M Liechty L Davis H Stopper

Loss of heterozygosity is one genetic change observed in many tumours. We do not know whether the loss of chromosomal material through micronucleus formation is a viable mechanism associated with, and possibly leading to, genetic disease. Previously, we treated L5178Y mouse lymphoma cells with four aneugens. Although these aneugens induced micronuclei containing predominantly whole chromosomes,...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006
Armen Nersesyan Michael Kundi Kambis Atefie Rolf Schulte-Hermann Siegfried Knasmüller

Micronuclei in exfoliated epithelial cells are widely used as biomarkers of cancer risk in humans. To elucidate the effect of different staining procedures on the outcome of such investigation, we conducted a study in which the micronuclei frequencies in oral mucosa cells of heavy smokers (n = 20) and nonsmokers (n = 10) were evaluated with nonspecific (Giemsa, May-Grünwald-Giemsa) and DNA-spec...

Journal: :Mutagenesis 2012
Atsushi Okamoto Koh-ichi Utani Noriaki Shimizu

A micronucleus is a small nucleus-like structure found in the cytoplasm of dividing cells that suffered from genotoxic stress. It is generally hypothesised that micronuclei content is eventually lost from cells, though the mechanism of how this occurs is unknown. If DNA located within the micronucleus is not replicated, it may explain the loss of micronuclei content. Because there had been no c...

Journal: :Mutagenesis 2011
Kimberly H Jones Timothy P York Jane Juusola Andrea Ferreira-Gonzalez Hermine H Maes Colleen Jackson-Cook

The primary aim of this study was to quantify genetic and environmental influences on the frequency of spontaneously occurring micronuclei in children and adults. To meet this aim, a total of 63 male and female twin pairs and 19 singletons (145 individuals) were evaluated, ranging in age from 7 to 85 years. Micronuclei frequencies significantly increased with age for both genders (r = 0.49, P <...

Journal: :journal of biomedical physics and engineering 0
a naeeji radiology technology department, school of allied medical sciences, shahid beheshti university of medical sciences, tehran, iran h mozdarani department of medical genetics, faculty of medical sciences, tarbiat modares university, tehran, iran a shabestani monfared cellular &amp; molecular biology research center, medical physics department, babol university of medical sciences, babol, iran f faeghi radiology technology department, school of allied medical sciences, shahid beheshti university of medical sciences, tehran, iran a a ahmadi north research center, pasteur institute of iran, amol, iran m gholami north research center, pasteur institute of iran, amol, iran

background: in many studies, chemicals and natural materials were tested to reduce the harmful effects of radiation. it is known that famotidine and vitamin c reduce dna damage. objective: the aim of this study was to evaluate the radioprotective effect of vitamin c, cimetidine and famotidine on gamma-radiation-induced damage on mouse bone marrow.  methods: six-to-seven week male nmri mice (28 ...

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