This review reports the progress on the recent development of micromixers. The review first presents the different micromixer types and designs. Micromixers in this review are categorized as passive micromixers and active micromixers. Due to the simple fabrication technology and the easy implementation in a complex microfluidic system, passive micromixers will be the focus of this review. Next,...

We evaluated the dynamic micromixing performances in slanted groove micromixers (SGM) and staggered herringbone micromixers (SHM) and quantitatively compared their differences using concentration vs. channel length profiles obtained from numerical stimulations. It is found that faster and finer mixing took place in the SHM and the chaotic mixing was more effective at locations closer to the gro...

This review surveys the advances of microvalves, micropumps, and micromixers within PCR microfluidic chips over the past ten years. First, the types of microvalves in PCR chips are discussed, including active and passive microvalves. The active microvalves are subdivided into mechanical (thermopneumatic and shape memory alloy), non-mechanical (hydrogel, sol-gel, paraffin, and ice), and external...

The previous studies of authors on passive micromixers indicated that the micromixers dividing the flow to several layers, such as rhombus micromixers and micromixers with obstacles in the middle of the mixing channel, have higher mixing degree than other types. Also, using of oscillatory inlet velocities is an active method to enhance the mixing efficiency of micromixers. Therefore, in this st...

Micromixing is a crucial process within microfluidic systems such as micro total analysis systems (μTAS). A state-of-art review on microstructured mixing devices and their mixing phenomena is given. The review first presents an overview of the characteristics of fluidic behavior at the microscale and their implications in microfluidic mixing processes. According to the two basic principles expl...

This paper presents an optimal control-based inverse method used to determine the distribution of the electrodes for the electroosmotic micromixers with external driven flow from the inlet. Based on the optimal control method, one Dirichlet boundary control problem is constructed to inversely find the optimal distribution of the electrodes on the sidewalls of electroosmotic micromixers and achi...

A microflow system consisting of micromixers and microtube reactors provides an effective method for the introduction of two electrophiles onto dibromobiaryls. Selective monolithiation of dibromobiaryls, such as 2,2'-dibromobiphenyl, 4,4'-dibromobiphenyl, 2,7-dibromo-9,9-dioctylfluorene, 2,2'-dibromo-1,1'-binaphthyl, and 2,2'-dibromobibenzyl with 1 equiv of n-butyllithium followed by the reacti...

This paper discusses a flexible layout design method of passive micromixers based on the topology optimization of fluidic flows. Being different from the trial and error method, this method obtains the detailed layout of a passive micromixer according to the desired mixing performance by solving a topology optimization problem. Therefore, the dependence on the experience of the designer is weak...

Passive micromixing can efficiently mix laminar flows through molecular and convective diffusion. Microstructures are expected to be efficient, easily integrated into micromixers, suitable for micromixers over a wide range of Re. This paper presents the enhancement effects multiscale lateral microstructures on flow field characteristics mixing efficiency numerical simulations at Re = 0.01–50. I...