Background: Neuroinflammation, as a major outcome of microglia activation, is an important factor for progression of neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. Microglial cells, as the first-line defense in the central nervous system, act as a source of neurotoxic factors such as nitric oxide (NO), a free radical which is involved in neuronal cell death. ...

The reaction between reducing sugars and protein free amines, known as the Maillar reaction results in the formation of advanced glycation endproducts (AGEs). AGE modification changes the structure of proteins to amyloid cross-beta structure. These protein structures can activate receptors known as RAGE on glial cells (microglia and astrocytes), and induce the expression of inducible nitric oxi...

multiple sclerosis (ms) is the most common autoimmune disease, especially among young’s. neuroinflammation results from inflammation in cns and it may cause different disorders and diseases .it is also known as a detriment in multiple sclerosis. in fact, it causes problems and symptoms in ms. in ms the self-immune cells attack the myelin of neurons, it maybe the nerve in brain or spinal cord. d...

Multiple sclerosis (MS) is the most common autoimmune disease, especially among young’s. Neuroinflammation results from inflammation in CNS and it may cause different disorders and diseases .It is also known as a detriment in multiple sclerosis. In fact, it causes problems and symptoms in MS. In MS the self-immune cells attack the myelin of neurons, it maybe the nerve in brain or spinal c...

The reaction between reducing sugars and protein free amines, known as the Maillar reaction results in the formation of advanced glycation endproducts (AGEs). AGE modification changes the structure of proteins to amyloid cross-beta structure. These protein structures can activate receptors known as RAGE on glial cells (microglia and astrocytes), and induce the expression of inducible nitric oxi...

autism spectrum disorder (asd) is a mental condition, present from early childhood, characterized by great difficulty in communicating and forming relationships with others and using language. in the last four decades many studies have shown that immune responses in different regions of brain play an important role in asd pathogenicity. a conservative estimate based on the research suggests tha...

Background: New evidence suggests an important role for spinal glial cells in development of opioid dependence. Curcumin, a component of the Curcuma Longa, has shown to act as a suppressor of microglial cells. The main goal of this study was to explore the attenuating effects of curcumin on morphine dependence with a focus on spinal microglial cells and inflammatory cytokines. Methods: In...

introduction: although aging is the most important risk factor for alzheimer's disease (ad), there is evidence indicating that neuroinflammation may contribute to the development and progression of the disease. several studies indicated that minocycline may exert neuroprotective effects in rodent models of neurodegenerative diseases. nevertheless, there are also other studies implying that...

Background: New evidence suggests an important role for spinal glial cells in development of opioid dependence. Curcumin, a component of the Curcuma Longa, has shown to act as a suppressor of microglial cells. The main goal of this study was to explore the attenuating effects of curcumin on morphine dependence with a focus on spinal microglial cells and inflammatory cytokines. Methods: In...

Background: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and NLRP3 in microglia remains poorly understood. Objective: To investigate w...