The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microballoons of Propranolol hydrochloride. An antihypertensive drug, Propranolol hydrochloride, is delivered through the microparticulate system using ethyl cellulose as the controlled release polymer. Microballoons were developed ...

Objective of present study involves preparation and evaluation of floating microballoons of indometacin as a model drug, to increase its residence time in the stomach without contact with the mucosa. The microballoons were prepared by the emulsion solvent diffusion technique using different ratio of acrylic polymers (Eudragit RS100 and Eudragit S 100) as carriers. The yield of microballoons was...

The objective of present investigation is to design a sustained release floating microballoons of Metformin HCl using two polymers of different permeability characteristics Cellulose Acetate Butyrate (MW of 16,000) and Eudragit RS 100 (MW of 150,000) using the oil-in-oil emulsion solvent evaporation method. The prepared microballoons were studied for drug release behavior in simulated gastric f...

Composite materials fabricated using hollow microspheres are called syntactic foams. Particulate filler composites such as syntactic foams, consisting of glass microballoons and epoxy resin, are desirable for applications that require high compressive and impact strengths and low thermal conductivities. However, for heat dissipation applications, filler additions are required to increase the th...

Epoxy binders containing microballoons ranging from 38.5 to 57.7% by volume were cast in a mold and cured, and the resulting slabs were sectioned to yield short-beam test coupons. The strength changes with microballoons content were noted. These reveal an increase from 3.87 to 5.79 MPa for a decrease in microballoons content from 57.7 to 38.5%. Mechanical data were correlated with fractographic...

BACKGROUND AND THE PURPOSE OF THE STUDY The purpose of the present investigation was to characterize, optimize and evaluate microballoons of Propranolol hydrochloride and to increase its boioavailability by increasing the retention time of the drug in the gastrointestinal tract. METHODS Propranolol hydrochloride-loaded microballoons were prepared by the non-aqueous O/O emulsion solvent diffus...

The aim of this study was to formulate and evaluate stavudine floating microballoons for controlled drug release. Initially, the drug-loaded low-density granular pellets were prepared with hydroxypropyl methylcellulose E5 grade and by using isopropyl alcohol as a granulating fluid. Further, the low-density granular pellets were subjected to microencapsulation by an emulsion evaporation techniqu...

The floating microballoons have been utilized to obtain prolonged and uniform release in the stomach. The objective of the present study involves design, development, and characterization of pentoxifylline loaded floating microballoons to prolong their gastric residence time. Pentoxifylline (trisubstituted xanthine derivative) loaded microballoons were prepared by the solvent evaporation techni...

The present investigation was aimed to formulate and evaluate the gastro-retentive floating microballoons of glipizide using hydrophilic polymers hydroxypropyl methylcellulose (HPMC) and Eudragit RS100 (RS 100) by emulsion solvent evaporation technique. The floating microballoons were evaluated using micromeritic properties, buoyancy, in vitro drug release, scanning electron microscopy and stab...

BACKGROUND AND THE PURPOSE OF THE STUDY The objective of the present work was to improve bioavailability of cepodoxime proxetil through gastroretentive microballoon formulation. METHODS Microballoons of cefpodoxime proxetil were formulated by solvent evaporation and diffusion method employing hydroxypropylmethyl cellulose (HPMC) and ethyl cellulose (EC) polymers and characterized for particle...