OBJECTIVES We examined changes in sleep quality and architecture in patients with minimal hepatic encephalopathy (MHE) and the impacts of sleep disruption on patient physical and psychological health. METHODS Ninety-eight MHE patients were examined by polysomnography (PSG) and the Pittsburg sleep quality inventory (PSQI). In addition, patients completed the SAS, SDS, and SCL-90 to examine the...

2 Title 3 Theta-rhythmic drive between medial septum and hippocampus in slow wave sleep and microarousal: A 4 Granger causality analysis 5 6 Abbreviated Title: Septohippocampal theta rhythm in sleep and microarousal 7 8 D. KANG, M. DING, I. TOPCHIY, L. SHIFFLETT, B. KOCSIS 9 10 J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 11 32611 12 Depar...

Sleep curtailment negatively affects cardiac activities and thus should be ameliorated by pharmacological methods. One of the therapeutic targets is melatonin receptors, which tune circadian rhythms. Ramelteon, a MT1/MT2 receptor agonist, has recently been developed to modulate sleep-wake To date, sleep-promoting effect ramelteon widely delineated, but whether treatment physiologically influenc...

OBJECTIVE Sleep disordered breathing with central apnea or hypopnea frequently occurs at high altitude and is thought to be caused by a decrease in blood CO(2) level. The aim of this study was to assess the effects of added respiratory dead space on sleep disordered breathing. METHODS Full polysomnographies were performed on 12 unacclimatized swiss mountaineers (11 males, 1 female, mean age 3...

Obstructive sleep apnea (OSA) is independently associated with dyslipidemia. Previous studies have demonstrated that sleep fragmentation can impair lipid metabolism. The present study aimed to identify whether sleep fragmentation is independently associated with dyslipidemia, in a large-scale, clinic-based consecutive OSA sample. This cross-sectional study was conducted among 2,686 patients who...

OBJECTIVE To evaluate the efficacies of transcutaneous stimulation of genioglossus on remaining mild-to-moderate obstructive sleep apnea syndrome (OSAS) after uvulopalatopharyngoplasty (UPPP). METHODS A total of 22 patients diagnosed with mild-to-moderate OSAS by polysomnography (PSG) after UPPP were recruited from Sleep Center of First Affiliated Hospital, Nanjing Medical University from Feb...

OBJECTIVE To determine the prevalence of nocturnal hypoxemia and its association with pulmonary function, nutritional status, sleep macrostructure, and obstructive respiratory events during sleep in a population of clinically stable children and adolescents with cystic fibrosis (CF). METHODS This was a cross-sectional study involving 67 children and adolescents with CF between 2 and 14 years ...

BACKGROUND Sphincter pharyngoplasty (SP) appears to be the more "physiologic" surgical technique to treat velopharyngeal incompetence (VPI). This procedure creates a dynamic sphincter of variable diameter and keeps the flexibility of the soft palate. SP also induces velopharyngeal size reduction, mainly in the transverse diameter, which may cause upper airway (UA) occlusions during sleep. AIM...