Bacterial infections of the dental pulp result in tissue destruction and periapical bone resorption. The availability of genetically engineered mouse strains is a major advantage in the use of this model system for studies of periapical pathogenesis. The main limitation of the mouse model is its small size, and the necessity for laborious histologic analyses to quantify periapical bone destruct...

Figure 1 [1] There are two levels of CT imaging small animals – miniand micro-CT. Mini-CT has a voxel resolution that is equivalent to whole body CT of the adult human. Thus, a 30 cm diameter human chest is represented with up to 500 pixels clinically, so a 2 cm mouse chest would be represented by 500, 40, μm pixels. Higher resolution scans at the microscopic level are truly micro-CT scans. I w...

PURPOSE In this paper we show that optimization-based autofocus may be used to overcome the instabilities that have, until now, made high-resolution theoretically-exact tomographic reconstruction impractical. To our knowledge, this represents the first successful use of theoretically-exact reconstruction in helical micro computed tomography (micro-CT) imaging. We show that autofocus-corrected, ...

In order to understand and to simulate the functional behaviour of porous structures during loading, quantitative knowledge of the relationship between the morphology and the mechanical behaviour is necessary. Therefore, the porous structures need to be quantified morphologically. In this research, the quantification will be performed by using micro-CT. However, to date, this technique encounte...

Aims Micro-CT is an established tool to evaluate the bone architecture in small animals. Especially in-vivo micro-CT is very popular, as it allows longitudinal (i.e. over time) follow-up of the evolution in the same animal. This way, changes in the bone structure over time can be assessed. Usually, bone parameters are measured separately in the different images. To be comparable, a similar loca...

Micron-scale computed tomography (micro-CT) is an essential tool for phenotyping and for elucidating diseases and their therapies. This work is focused on preclinical micro-CT imaging, reviewing relevant principles, technologies, and applications. Commonly, micro-CT provides high-resolution anatomic information, either on its own or in conjunction with lower-resolution functional imaging modali...

ct image quality has been affected by many factors such as kvp, ma, exposure time, alogorithm and section thickness. gantry tilt has the main role in visualization of the temporal bone anatomic structures. in this study, we tried to optimize these factors to determine the best gantry tilt. this study was performed on the human skull phantom and then extended to 15 patients. the phantom was made...

BACKGROUND Shape of the dental root canal is highly patient specific. Automated identification methods of the medial line of dental root canals and the reproduction of their 3D shape can be beneficial for planning endodontic interventions as severely curved root canals or multi-rooted teeth may pose treatment challenges. Accurate shape information of the root canals may also be used by manufact...