objective(s) quinazolinones are heterocyclic compounds, with biological and pharmacological activities, such as inhibiting some proteins, enzymes and reducing blood lipids. materials and methods following previous results of our group, effects of two new derivatives of quinazolinones 9(3)-quinazolinone-2-propyl-2-phenylethyl (qppe) and 9(3)-quinazolinone-2-ethyl-2-phenylethyl (qepe) on livers, ...

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us damages to the ovary storage and the matrix muscle state. some of these patients may admit to infertility clinics for having pregnancy and on the other hand hormonal administration for superovulation induction is a routine procedure in assisted reproduction technology (art) clinics.objective: this study aimed to investigate fertility and fetuses of hormone treated super ovulated female mice ...

Background: One in every 250 newborns is exposed to antiepileptic drugs, inutero .The risk of congenital malformations in newborns, prenatally exposed to antiepileptic drugs (AEDs), is around 5% which is 2 to 2.5 times that of general population; while carbamazepine (CBZ) and valproate (VPA) still provide the treatment of choice in most forms of epilepsy, being efficacious in approximately two-...

objective: silybum marianum has been used for centuries in herbal medicine for treatment of liver diseases. currently, there is no data available on the possible effects of silymarin on fetal development. this study aimed to investigate the teratogenic effect of silymarin on balb/c mice fetuses. materials and methods: a total of 40 pregnant mice were divided into 4 groups of 10 mice each. three...

background: methamphetamine (ma) is a potent psychomotor stimulant with high abuse and addictive potential. ma is a neurotoxic drug which is widely abused by females of childbearing age, raising serious public health concerns in terms of exposure of the fetus to the drug. neurotoxic effects of ma on adult are well known, such as dopaminergic nerve terminal degeneration and cell death in regions...

in this work, we tried to know something more about the embryotoxicity effects of the doses of 50, 200, 400 mg/kg/day of ranitidine of (h2 antihistaminic agent) by intraperitoneal administration on mice. the studies were performed on albino mice kept under specific conditions and a constant dark-light cycle at 24+1c and 55+5% relative humidity. generally, the animals were acclimatized for four ...

Objective: Silybum marianum has been used for centuries in herbal medicine for treatment of liver diseases. Currently, there is no data available on the possible effects of silymarin on fetal development. This study aimed to investigate the teratogenic effect of silymarin on BALB/c mice fetuses. Materials and Methods: A total of 40 pregnant mice were divided into 4 groups of 10 mice each. Three...

disodium glycyrrhetinic acid hemiphthalaic (gap) was evaluated for developmental toxicity in pregnant nmri mice. gap was administered intrapcritoneally on days s, 9, 10, of gestation at doses of 0, 25, 50 and 75 mg/kg/dav. on gestation day of is, after operational delivery, the fetuses were examined for soft tissue, external and skeletal defects. increased absorptions, dead fetuses, and reduce ...

Mice produce litters containing many pups, and the female fetuses that develop between male fetuses have significantly higher concentrations of the male sex steroid testosterone in both their blood and amniotic fluid than do females that develop between other female fetuses. These two types of females differ during later life in many sexually related characteristics. Thus, individual variation ...