introduction: as a physical treatment, electrochemical therapy (echt) has provided an effective and useful  approach  for  treating  localized  tumors.  the  chemical  changes  due  to  a  direct  electric  current  destroy  the  tumor. this study evaluates the effect of electrical dose and polarity on the efficacy of the treatment of a  colon tumor model.  materials and methods: in order to in...

objective(s):sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. the present investigation attempted to evaluate the potential of anti-cancer persian gulf sea cucumber species holothuria arenicola (h. arenicola) aqueous extract on mice colon carcinoma cells in vitro and in ...

Objective(s):Sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. The present investigation attempted to evaluate the potential of anti-cancer Persian Gulf sea cucumber species Holothuria arenicola (H. arenicola) aqueous extract on mice colon carcinoma cells in vitro and in ...

a man with metastatic carcinoma of the colon had a bone scan which revealed urinary retention in the leftkidney. ten months later, a tc-99m-dtpa renai glomerular study showed the left kidney to have only 8% oftotal renal function. fifteen months after that, (he same kidney demonstrated 9% of total function, while theright kidney had evolving obstruction due to his neoplasm. the case shows that ...

Purpose: Colon cancer is amongst the most commonly diagnosed carcinoma globally and ranks 3rd highest of all kinds tumors. In present study effect oxobedfordia acid on colon cell viability colorectal tumor growth in vivo was investigated.Methods: Cytotoxicity SW480, HCT116, FHC cells evaluated by MTT assay. mice induced implanting subcutaneously 2 x 106 HT-29 cells/mouse right flank. Various pa...

Abstract Tumor associated immunosuppressive cells limit the efficacy of CAR T against solid tumors. To alter immunosuppression in tumor microenvironment, were armored with an IL-2 superkine (Super2) and alarmin IL-33 adoptively transferred into immunocompetent mice established primary or metastatic B16F10 melanoma intradermal MC38 colon carcinoma. We show that Super2-IL-33 universally promoted ...

Short-chain fatty acids, metabolites produced by colonic microbiota from fermentation of dietary fiber, act as anti-inflammatory agents in the intestinal tract to suppress proinflammatory diseases. GPR109A is the receptor for short-chain fatty acids. The functions of GPR109A have been the subject of extensive studies; however, the molecular mechanisms underlying GPR109A expression is largely un...

Four major carcinoembryonic antigen-related glycopeptides (Mr 180,000, 160,000, 50,000, and 40,000) were detected in SW948 colon carcinoma cells and in colon adenocarcinoma tissue using a monoclonal antibody (C(4)20-32) generated by immunizing mice with SW1222 human colon carcinoma cells. Only the Mr 50,000 polypeptide was immunoprecipitated from normal colon mucosa by this antibody. Binding st...

A human colon carcinoma cell line, HC84S, was established in serum-supplemented medium from a colon tumor line T84 transplanted in nude mice. These cells also grew in a serum-free, synthetic medium supplement with insulin, glucagon, epidermal growth factor, transferrin, hydrocortisone, triiodothyronine, selenium, and ascorbic acid. HC84S cells grew 3 times faster in this medium than in serum-co...