نتایج جستجو برای: MiR-383

تعداد نتایج: 49268  

Journal: :iranian journal of basic medical sciences 0
zhixiong fang department of infectious disease, xiangtan city central hospital, xiangtan, people's republic of china langqiu he department of infectious disease, xiangtan city central hospital, xiangtan, people's republic of china hui jia department of infectious disease, xiangtan city central hospital, xiangtan, people's republic of china qiusheng huang department of infectious disease, xiangtan city central hospital, xiangtan, people's republic of china dan chen edong healthcare city hospital of traditional chinese medicine, inefections disease hospital, huangshi, people's republic of china zhiwei zhang cancer research institute, university of south china, key laboratory of cancer cellular and molecular pathology of hunan provincial university, hengyang, people's republic of china

objective(s): to explore the correlation between expression patterns and functions of mir-383 and ldha in hepatocellular cancer (hcc). materials and methods: we detected the expression of mir-383 and ldha in 30 hcc tissues and their matched adjacent normal tissues using qrt-pcr. then we performed mtt assay, foci formation assay, transwell migration assay, glucose uptake assay and lactate produc...

Objective(s): To explore the correlation between expression patterns and functions of miR-383 and LDHA in hepatocellular cancer (HCC). Materials and Methods: We detected the expression of miR-383 and LDHA in 30 HCC tissues and their matched adjacent normal tissues using qRT-PCR. Then we performed MTT assay, foci formation assay, transwell migration assay, glucose uptake assay and lactate produc...

2017
Zhixiong Fang Langqiu He Hui Jia Qiusheng Huang Dan Chen Zhiwei Zhang

OBJECTIVES To explore the correlation between expression patterns and functions of miR-383 and LDHA in hepatocellular cancer (HCC). MATERIALS AND METHODS We detected the expression of miR-383 and LDHA in 30 HCC tissues and their matched adjacent normal tissues using qRT-PCR. Then we performed MTT assay, foci formation assay, transwell migration assay, glucose uptake assay and lactate producti...

2017
Shasha Zhao Xinyuan Gao Shuzhi Zang Yunxia Li Xianjun Feng Xiaomei Yuan

Lung cancer is the leading cause of cancer-associated mortality worldwide. MicroRNAs (miRNAs/miRs) serve a role in the occurrence and development of lung cancer. The aim of the present study was to analyze the expression and function of the proliferation-associated miR-383-5p in lung adenocarcinoma (LAC). Samples of human LAC and matched adjacent normal lung tissues were surgically removed, and...

2009
Jinglian Wang Bing Li

Lung cancer is the most common cause of deaths among all cancers around the world and non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases. In this study, we investigated the expression level of miR-383 and its biological function in NSCLC. Firstly, we observed miR-383 down-regulation and HDAC2 up-regulation in NSCLC by qRT-PCR and Western blot, respectivel...

2018
Ying Cui Le-Gao Chen Hai-Bo Yao Jun Zhang Ke-Feng Ding

Increasing evidence demonstrates that microRNAs (miRNAs/miRs), a type of non-coding small RNA, can regulate tumor cell migration, invasion and metastasis, and may therefore serve a major function in the occurrence and development of tumors. The present study investigated the effect of miR-383 on the proliferation, migration and invasion of colon cancer HT-29 and LoVo cell lines. The expression ...

2018
Xinlei Wang Guoyou Ding Wei Lai Shiwen Liu Jun Shuai

Anesthesia-induced cognitive impairment is a recognized clinical phenomenon. The present study aimed to investigate the effect of microRNA-383 (miR-383) expression on propofol-induced learning and memory impairment. In total, 48 male Sprague-Dawley rats (weight, 250±10 g) were randomly divided into four groups (n=12 each): Control group, and three groups of rats that were anesthetized with prop...

2011
Joanna Boguslawska Anna Wojcicka Agnieszka Piekielko-Witkowska Adam Master Alicja Nauman

Type 1 iodothyronine deiodinase (DIO1) catalyses the conversion of prohormone thyroxine to the active thyroid hormone 3,3',5-triiodothyronine (T3), important regulator of cell proliferation and differentiation. DIO1 expression is reduced in the most common type of kidney neoplasia, clear cell Renal Cell Carcinoma (ccRCC). MicroRNAs are small, non-coding RNAs that regulate gene expression at pos...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تبریز - پژوهشکده علوم زیستی 1393

سرطان کلورکتال یکی از شایع ترین سرطان های دستگاه گوارش و سومین علت شایع از مرگ های در ارتباط با سرطان در دنیا می باشد و این در حالی هست که چهارمین سرطان شایع در ایران بوده و طی سالهای اخیر افزایش قابل ملاحظه ای داشته هست. میکروrnaها rna های کوچک دو رشته ای به طول 20 تا 24 نوکلئوتید و یک کلاس از rna های غیر کد کننده کوچک و از تنظیم کننده های بعد از رونویسی هستند که در یوکاریوتها نقش داشته واز ط...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017
Guo-Jun Wei Gang An Zuo-Wei Shi Kai-Fu Wang Ying Guan Yan-Song Wang Bo Han En-Ming Yu Peng-Fei Li Da-Ming Dong Li-Ping Wang Zhao-Wei Teng De-Lai Zhao

BACKGROUND/AIMS Transplantation of bone-marrow-derived mesenchymal stem cells (MSCs) has been used to treat spinal cord injury (SCI) to enhance tissue repair and neural cell regeneration. Glial cell line derived neurotrophic factor (GDNF) is an identified neural growth and survival factor. Here, we examined whether modification of GDNF levels in MSCs may further increase the potential of MSCs i...

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