The convulsant drug, metrazol, has long been known to produce experimelltal seizures of the grand ma1 type and, more recently, has been employed clinically, either in shock therapy for patients with mental disease (11) or as an aid in the diagnosis of suspected epilepsy (2, 3, 8, 12, 16). Administration of ~ubconvuls i~~ doses of metrazol has been used to provoke abnormal discharge in the elect...

METRAZOL therapy in schizophrenia was started at the Worcester State Hospital in the summer of 1937. A study of the influence of metrazol on the electroencephalogram was begun at the same time in the hope of throwing some light on the mechanisms underlying this type of therapy. Twenty-eight injections of 10-per cent. metrazol (cardiazol or pentamethylenetetrazol) were given to 11 schizophrenic ...

potentials were recorded from "idle" cells in the cerebral cortex of the cat. Records were made during repetitive stimulation of the cortical surface and during Metrazol induced paroxysmal activity. 2. The intraand extra-cellular potentials induced by either stimulation of cortical surface or Metrazol injection were of opposite polarity, revealing that the intracellularly recorded potential was...

The report by Shaw et al. (1954) on the effectiveness of Megimide

‰H –ì Žõ • E ‹à OEË —m • EŠp‰i • • • v Recently, Kase (1-2) put forward the remarkable hypothesis that the development of tolerance to morphine is due to the changes of blood-cerebrospinal fluid-barrier. This hypothesis was based on the experimental results that morphinized dogs lost their acquired tolerance to morphine by elec trical shock or chemical seizures resulting from the alteration of ...