The assessment of methodological quality (MQ) in biomedical research is an area of dynamic development over recent years globally. Understood as a complex and multidimensional construct, several groups have been proposed tools for its evaluation, between them our group has designed and validated scales to assess MQ in therapy, diagnosis and prognosis studies. However, as with other instruments,...

Randomised trials vary in methodological quality, and flaws in trial conduct can lead to biased estimation of the intervention effect. If a meta-analysis makes no allowance for methodological flaws, there’s a danger that the results could be biased and over-precise, or that some lowerquality trials could be given too much influence in the meta-analysis. Cochrane review authors now use a specifi...

BACKGROUND The stepped wedge cluster randomised trial (SW-CRT) is increasingly being used to evaluate policy or service delivery interventions. However, there is a dearth of trials literature addressing analytical approaches to the SW-CRT. Perhaps as a result, a significant number of published trials have major methodological shortcomings, including failure to adjust for secular trends at the a...

OBJECTIVES To compare the methodological and reporting quality of systematic reviews by authors from China and those from the United States (USA). STUDY DESIGN AND SETTING From systematic reviews of randomized trials published in 2014 in English, we randomly selected 100 from China and 100 from the USA. The methodological quality was assessed using the Assessing the Methodological Quality of ...

Studies reporting sociometric assessments based on nominations have been characterized by important methodological inconsistencies when conducted in the middle school context. The purpose of this study was to examine (1) the possibility of a response bias when participants are provided with a long roster sorted alphabetically, (2) the impact of including or not other-sex peers in the voting pop...

OBJECTIVES Published negative studies should have the same rigour of methodological quality as studies with positive findings. However, the methodological quality of negative versus positive studies is not known. The objective was to assess the reported methodological quality of positive versus negative studies published in Indian medical journals. DESIGN A systematic review (SR) was performe...

This article asserts that traditionally dominant models of health promotion in the US are fairly characterized by methodological individualism. This schema produces a focus on the individual as the node of intervention. Such emphasis results in a number of scientific and ethical problems. I identify three principal ethical deficiencies: first, the health promotions used are generally ineffectiv...

Cost-effective prevention strategies to prevent weight gain and the development of obesity should be based on appropriate knowledge of the determinants of weight gain. The body of evidence on the dietary determinants of weight gain is, however, fragmentary at best, partly because inappropriate research methods are used to study the determinants of obesity under normal circumstances. Evidence fr...

BACKGROUND Overviews of reviews (overviews) compile information from multiple systematic reviews (SRs) to provide a single synthesis of relevant evidence for decision-making. It is recommended that authors assess and report the methodological quality of SRs in overviews-for example, using A MeaSurement Tool to Assess systematic Reviews (AMSTAR). Currently, there is variation in whether and how ...