Introduction: Methemoglobinemia is a rare serious hematological disorder, which is one of the causes of cyanosis in childhood, requiring emergency treatment. It may occur in congenital and acquired circumstances. Congenital methemoglobinemia can be a result of a genetic defect in erythrocyte metabolism and hemoglobin structure. Case Report: Acquired methemoglobinemia occurs in individuals expos...

A case is reported in which a patient developed methemoglobinemia-induced cyanosis while under general anesthesia during surgery for multiple fascial space infections. The cause of methemoglobinemia was 20% benzocaine spray used for local anesthesia before intubation. Acutely developing methemoglobinemia is infrequently encountered in clinical practice. When confronted with cyanosis in the abse...

Methemoglobinemia (MetHb) is an uncommon cause of central cyanosis and hence, not frequently considered in the differential diagnosis. Methemoglobin abnormal form hemoglobin which produced physiologically due to autooxidation. If this process autooxidation disturbed, either genetic or exogeneous drugs/toxins, its level rises blood leading tissue hypoxia. It causes when exceeds 3%. We present ca...

Congenital methemoglobinemia can be caused by mutations involving five different genes. We studied the etiology and molecular biology of eight consecutive patients with methemoglobinemia. Four had b5R mutations; two were novel. A novel intronic mutation caused markedly reduced mRNA resulting in type II methemoglobinemia. Three patients had acquired methemoglobinemia without any b5R mutations.

Methemoglobinemia, although rare, must be considered in surgical patients presenting with acute respiratory distress and cyanosis. We report two cases of methemoglobinemia in patients undergoing aortic reconstruction. The first patient developed methemoglobinemia while on a nitroglycerin infusion, and the second after receiving benzocaine spray before intubation. Both patients were treated with...

OBJECTIVE This study aimed to determine the etiologic factors of acquired methemoglobinemia in infants younger than three months in our region. METHODS This study was carried out retrospectively in infants with methemoglobinemia admitted to Karadeniz Technical University, Pediatric Clinic, during the period 2000-2009. Infants with methemoglobinemia were identified according to the medical rec...

This study had the aim of investigating occurrences of methemoglobinemia among individuals with glucose-6-phosphate dehydrogenase deficiency during treatment for malaria infection using primaquine. Patients with a diagnosis of malaria caused by Plasmodium vivax or the V+F mixture (Plasmodium vivax + Plasmodium falciparum) were selected. Group 1 consisted of 74 individuals with a clinical diagno...

Ingestion of nitrates in drinking water has long been thought to be a primary cause of acquired infantile methemoglobinemia, often called blue baby syndrome. However, recent research and a review of historical cases offer a more complex picture of the causes of infantile methemoglobinemia. Gastrointestinal infection and inflammation and the ensuing overproduction of nitric oxide may be the caus...

Methemoglobinemia is a rare condition in which the iron in hemoglobin is stabilized in the ferric (Fe(3+)) form, making it unable to bind oxygen and leading to tissue hypoxia and possibly death. The condition may be hereditary or acquired, the latter resulting from ingestion or application of common oxidizing agents such as lidocaine. As management of methemoglobinemia depends on prompt recogni...

Acute methemoglobinemia may be caused by topical anesthetics and other oxidizing medications commonly prescribed by Family Physicians. Without knowledge of this potentially lethal condition, delay in diagnosis and treatment is likely. Methemoglobinemia should be considered in any patient presenting with cyanosis, particularly after the use of oxidizing medications. We describe a case of methemo...