results patients reported that their use of methamphetamine was motivated by methadone’s side effects and encouraged by family and friends who promoted methamphetamine use to assuage the side effects of methadone in the early stages of treatment before the appearance of methadone maintenance therapy’s effects on their life. patients and methods to gain a better understanding of patients’ motiva...

background: methadone is considered a long-acting opioid agonist which is widely used in the treatment of drug addiction. it is believed that opioids can cause erectile dysfunction (ed) by inhibiting gonadotropin and testosterone release. this study is aimed at defining the possible effects of conservative treatment with methadone on erectile dysfunction in the addicts. methods: a total of 382 ...

detoxification of children who are born from substance dependent mothers or those who are substance dependent themselves as a result of being abused by their families is a major concern. this report describes withdrawal symptoms and the way of abstinence in a 2.5 year-old girl who was dependent to opium. âfter that she was given opium for nearly two years suppress withdrawal symptoms, methadone...

Methadone maintenance treatment (MMT) is the major tapering therapy for morphine addictive patients. There have gender differences reported in response to MMT. This study discovered that the estrogen-response element single nucleotide polymorphism (ERE-SNP; rs16974799, C/T) of cytochrome 2B6 gene (cyp2b6; methadone catabolic enzyme) responded differently to MMT dosing. Oestradiol was associated...

Methadone maintenance therapy for the treatment of opioid dependence continues to carry a social stigma. Until recently, patients on methadone were not considered for liver transplantation. We describe the first case of a patient on methadone who received a liver transplant for end stage liver disease and was successfully treated for recurrent hepatitis C. More than five years post transplant a...

BACKGROUND Injection drug use (IDU) and heterosexual virus transmission both contribute to the growing mixed HIV epidemics in Eastern Europe and Central Asia. In Ukraine-chosen in this study as a representative country-IDU-related risk behaviors cause half of new infections, but few injection drug users (IDUs) receive methadone substitution therapy. Only 10% of eligible individuals receive anti...

background: addiction to narcotics ‎can cause serious problems and ‎monetary losses. therapeutic ‎success can be predicted ‎through identifying lapse risk ‎factors.‎ objective: determining job risk ‎factor of lapse.‎ methods: this was a cross ‎sectional study on 351 addicts ‎visiting five methadone clinics. a ‎data collection sheet consisting ‎of questions on demographic ‎and job information wa...

Methadone remains the most common form of pharmacological therapy for opioid dependence; however, there is a lack of explanation for the reports of its relatively low success rate in achieving complete abstinence. One hypothesis is that in vivo binding of methadone to the plasma glycoprotein alpha-1-acid glycoprotein (AGP), to a degree dependent on the molecular structure, may render the drug i...