Objective(s): The molecular basis of “metabolically healthy obese” and “metabolically unhealthy non-obese” phenotypes is not fully understood. Our objective was to identify metabolite patterns differing in obese (metabolically healthy vs unhealthy (MHO vs MUHO)) and non-obese (metabolically healthy vs unhealthy (MHNO vs MUHNO)) individuals. Materials ...

BACKGROUND Conflicting data exist about the cardiovascular risk of metabolically healthy obese persons. The prognostic value of C-reactive protein (CRP) in this intriguing group is unknown. We assessed the association between CRP levels and the risk of coronary heart disease (CHD) in metabolically healthy persons with abdominal obesity. METHODS AND RESULTS In the European Prospective Investig...

OBJECTIVE Obesity often clusters with other major cardiovascular disease risk factors, yet a subset of the obese appears to be protected from these risks. Two obesity phenotypes are described, (i) "metabolically healthy" obese, broadly defined as body mass index (BMI) ≥ 30 kg/m(2) and favorable levels of blood pressure, lipids, and glucose; and (ii) "at risk" obese, BMI ≥ 30 with unfavorable le...

posity is used, the metabolically healthy but obese phenotype is a benign condition, with a better prognosis (30–50% lower risk) for mortality and morbidity than metabolically abnormal obese people. Interestingly, no difference in the prognosis is observed between metabolically healthy but obese individuals and metabolically healthy normal-fat individuals once fitness is accounted for, suggesti...

Obesity is recognized a leading factor contributing in diabetes and cardiovascular (CV) disease development worldwide. Among obese individuals at least two phenotypes are determined, i.e. metabolically healthy obese and metabolically non-healthy obese. Subjects with one or other phenotype appear to be distinguished in CV risk and diabetes. Although lack of strong definition of metabolically hea...

background: metabolically obese normal-weight (monw) children and adolescents are characterized by body mass index (bmi) lower than +1sd with metabolic disorders such as hyperglycemia, hypertriglyceridemia, and/or hypertension. this study wants to determine prevalence of monw, metabolically benign normal weight (mbnw), metabolically abnormality obese (mao) and compare the components of metaboli...

BACKGROUND The metabolic consequences of obesity are associated with an imbalance of adipocytokines, e.g. adiponectin. However, some obese subjects remain metabolically healthy and have adiponectin levels similar to normal body weight subjects. Current estimates of the prevalence of obesity in Estonia have relied only on self-report data. OBJECTIVES To estimate the prevalence of obesity in Es...

The risk of type 2 diabetes among obese adults who are metabolically healthy has not been established. We systematically searched Medline (1946-August 2013) and Embase (1947-August 2013) for prospective studies of type 2 diabetes incidence (defined by blood glucose levels or self-report) among metabolically healthy obese adults (defined by body mass index [BMI] and normal cardiometabolic cluste...