meningococcal disease remains a significant global public health and is unique among causes of bacterial meningitis and sepsis where it not only causes sporadic disease but also outbreaks. meningococcal disease has a rapid onset with high mortality. the understanding of immunopathogenesis is crucial for development of novel therapeutic strategies and vaccines designed against meningococcal dise...

Meningococcal disease remains a significant global public health and is unique among causes of bacterial meningitis and sepsis where it not only causes sporadic disease but also outbreaks. Meningococcal disease has a rapid onset with high mortality. The understanding of immunopathogenesis is crucial for development of novel therapeutic strategies and vaccines designed against meningococcal dise...

Meningococcal diseases are serious threats to global health, and new vaccines specifically tailored to meet the age-related needs of various geographical areas are required. This paper focuses on the meningococcal conjugate vaccines developed by GSK Biologicals. Two combined conjugate vaccines were developed to help protect infants and young children in countries where the incidence of meningoc...

The clinical presentations of meningococcal diseases other than meningitis or meningococcemia may lead to erroneous diagnosis. Although several reports have described unusual meningococcal diseases, the Neisseria meningitidis strains involved in these forms have been poorly characterized. In this study, meningococcal arthritis and pericarditis were confirmed by isolation of N. meningitidis and/...

651. Epidemiology of Serogroup B Meningococcal Outbreaks and Interim Guidelines for the Use of an Unlicensed Serogroup B Vaccine Under a CDCSponsored IND for the Control of Outbreaks in Organizational Settings Sarah Meyer, MD, MPH; Jessica Macneil, MPH; Amy Blain, MPH; Thomas a. Clark, MD, MPH; Amanda Cohn, MD; For the Meningococcal Outbreak Work Group,; Meningitis and Vaccine Preventable Disea...

Editorial On December 11, 2012, the Korean military authorities made an official announcement that all recruits will receive a quadrivalent (group A, C, Y, and W-135) meningococcal conjugate vaccine (Menveo [1]. The meningococcal outbreak at the Nonsan Recruit Training Center in April 2011 raised public awareness of the need for a meningococcal vaccination for the Republic of Korea Army (ROKA)....