the aim of our work was to compare cytotoxic and membrane-damaging effects of o. majorana l. essential oil and linalool on hep g2 and to investigate their possible protective (antioxidant) effects against h2o2 induced membrane damage. the oils were investigated by gc and gc-ms and antioxidant activity was evaluated by dpph and -carotene–linoleic acid assays. assessment of cell viability was ma...

The aim of our work was to compare cytotoxic and membrane-damaging effects of O. majorana L. essential oil and linalool on Hep G2 and to investigate their possible protective (antioxidant) effects against H2O2 induced membrane damage. The oils were investigated by GC and GC-MS and antioxidant activity was evaluated by DPPH and -carotene–linoleic acid assays. Assessment of cell viability was ma...

The aim of our work was to compare cytotoxic and membrane-damaging effects of O. majorana L. essential oil and linalool on Hep G2 and to investigate their possible protective (antioxidant) effects against H2O2 induced membrane damage. The oils were investigated by GC and GC-MS and antioxidant activity was evaluated by DPPH and -carotene–linoleic acid assays. Assessment of cell viability was ma...

The unexpected enhancement of alkalinee phosphatase (ALP) activity in the serum of a group of STZ-diabetic rats recieving the Teucrium polium extract (with hypoglycaemic property) may be attributed to its probable side effects. In order to get a more precise knowledge about this subject, we evaluated the effect of T. polium extract on the plasma membrane ALP activity of K562 cell line. Our data...

The unexpected enhancement of alkalinee phosphatase (ALP) activity in the serum of a group of STZ-diabetic rats recieving the Teucrium polium extract (with hypoglycaemic property) may be attributed to its probable side effects. In order to get a more precise knowledge about this subject, we evaluated the effect of T. polium extract on the plasma membrane ALP activity of K562 cell line. Our data...

Bothropstoxin-I (BthTx-I) is a myotoxic phospholipase A(2) variant present in the venom of Bothrops jararacussu, in which the Asp(49) residue is replaced with a lysine, which damages artificial membranes by a Ca(2+)-independent mechanism. Wild-type BthTx-I and the mutants Lys(49)-->Asp, His(48)-->Gln and Lys(122)-->Ala were expressed in Escherichia coli BL21(DE3) cells, and the hydrolytic, myot...