hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. today this technology has found its place in the array of pharmaceutical manufacturing operations. melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...

Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...

Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...

Solid dispersion is molecular dispersion of drug in a polymer matrix which leads to improved solubility and hence better bioavailability. Solvent evaporation technique was employed to prepare films of different combinations of polymers, plasticizer, and a modal drug sulindac to narrow down on a few polymer-plasticizer-sulindac combinations. The sulindac-polymer-plasticizer combination that was ...

Polymers for hot melt extrusion must exhibit thermoplastic characteristics in order to permit the melt extrusion process and they must be stable at extrusion temperatures. Other relevant characteristics are: suitable glass transition temperature (Tg) of 50–180 °C, low hygroscopicity and no toxicity since larger amounts of polymer are used [1]. Extrudability of a polymer is mainly determined by ...

A study utilizing isotactic poly(4-methyl-1-pentene) (PMP) was undertaken to investigate a three stage process (melt-extrusion/annealing/uniaxial-stretching) (MEAUS) employed to produce microporous films. The results of this study will be reported in the course of two papers. In this first part, three PMP resins were melt-extruded into tubular films (blowup ratio; BUR = 1), where the resins eac...

A two part study utilizing polyoxymethylene (POM) was undertaken to investigate a three stage process (Melt-Extrusion/Annealing/Uniaxial-Stretching) (MEAUS) employed to produce microporous films. In this first part, three POM resins (D, E & F) were melt-extruded into tubular films (blowup ratio; BUR = 1), where resin D has a higher weight average molecular weight (Mw) than resin E but both poss...

Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug ...

Fibrous filters were fabricated using a novel melt co-extrusion and two-dimensional multiplication technology combined with a high pressure water jet delamination technique. The filters made from polypropylene (PP) / polyamide 6 (PA6) system exhibited micro to nano scale fibers having uniform fiber distribution and superior mechanical properties. Effects of film draw ratio upon co-extrusion on ...

In the past two decades, the repair and reconstruction of musculoskeletal tissues using biodegradable scaffold materials has emerged as one of the most promising approaches in tissue engineering. The aim of this study is to process, via hot melt extrusion, the biodegradable and biocompatible polymeric materials; poly(ethylene oxide) (PEO), poly(ethylene glycol) (PEG), ⍺lactose monohydrate and p...