نتایج جستجو برای: Melanocyte

تعداد نتایج: 4983  

ابراهیمی, علی , بیدمشکی‌پور, علی , غلامی, کیکاووس , مصطفایی, علی , منصوری, کامران , مهرابی, مریم , یارانی, رضا , یاری, خیراله ,

Background: Primary culture takes place following the cell isolation from tissues. Isolation and culture of melanocytes based on their roll in the protection of body against hazardous sun rays, production of skin, cornea and hair color is really important. This study was done to set isolation, culture and proliferation of melanocytes from children foreskin and adult eyelashes, and also comparis...

Journal: :journal of skin and stem cell 0
zohreh jadali skin and stem cell research center, tehran university of medical sciences, tehran, iran; school of public health, tehran university of medical sciences, tehran, iran; skin and stem cell research center, tehran university of medical sciences, tehran, iran. tel: +98-2122215558, fax: +98-2122674977

2017
Laura Vibert Gerardo Aquino Ines Gehring Tatiana Subkankulova Thomas F. Schilling Andrea Rocco Robert N. Kelsh

A role for Wnt signaling in melanocyte specification from neural crest is conserved across vertebrates, but possible ongoing roles in melanocyte differentiation have received little attention. Using a systems biology approach to investigate the gene regulatory network underlying stable melanocyte differentiation in zebrafish highlighted a requirement for a positive-feedback loop involving the m...

Journal: :PLoS Genetics 2007
Chao-Tsung Yang Anna E Hindes Keith A Hultman Stephen L Johnson

The establishment of a single cell type regeneration paradigm in the zebrafish provides an opportunity to investigate the genetic mechanisms specific to regeneration processes. We previously demonstrated that regeneration melanocytes arise from cell division of the otherwise quiescent melanocyte precursors following larval melanocyte ablation with a small molecule, MoTP. The ease of ablating me...

Journal: :Development 2006
Chao-Tsung Yang Stephen L Johnson

We developed a method to efficiently ablate a single cell type, the zebrafish melanocyte, and study the mechanisms of its regeneration. We found that a small molecule, (2-morpholinobutyl)-4-thiophenol (MoTP), specifically ablates zebrafish larval melanocytes or melanoblasts, and that this melanocytotoxicity is dependent on tyrosinase activity, which presumably converts MoTP to cytotoxic quinone...

2011
Emma R. Greenhill Andrea Rocco Laura Vibert Masataka Nikaido Robert N. Kelsh

The mechanisms generating stably differentiated cell-types from multipotent precursors are key to understanding normal development and have implications for treatment of cancer and the therapeutic use of stem cells. Pigment cells are a major derivative of neural crest stem cells and a key model cell-type for our understanding of the genetics of cell differentiation. Several factors driving mela...

2010
Karin Loser Thomas Brzoska Vinzenz Oji Matteo Auriemma Maik Voskort Verena Kupas Lars Klenner Cornelius Mensing Axel Hauschild Stefan Beissert Thomas A. Luger

BACKGROUND The neuropeptide alpha-melanocyte-stimulating hormone is well known as a mediator of skin pigmentation. More recently, it has been shown that alpha-melanocyte-stimulating hormone also plays pivotal roles in energy homeostasis, sexual function, and inflammation or immunomodulation. Alpha-melanocyte-stimulating hormone exerts its antiinflammatory and immunomodulatory effects by binding...

Journal: :Science 2005
Emi K Nishimura Scott R Granter David E Fisher

Hair graying is the most obvious sign of aging in humans, yet its mechanism is largely unknown. Here, we used melanocyte-tagged transgenic mice and aging human hair follicles to demonstrate that hair graying is caused by defective self-maintenance of melanocyte stem cells. This process is accelerated dramatically with Bcl2 deficiency, which causes selective apoptosis of melanocyte stem cells, b...

Journal: :The Journal of Experimental Medicine 1982
A N Houghton M Eisinger A P Albino J G Cairncross L J Old

The surface antigens of melanocytes from newborn and adult skin have been analyzed with monoclonal antibodies detecting cell surface antigens of malignant melanoma. Antigenic markers that distinguish early, intermediate, and mature stages in melanocyte differentiation have been defined. The characteristics of the normal melanocyte precursor have been inferred from the features of melanomas that...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید