Introduction: Radiation therapy is one of the major modalities that have long been used in cancer treatment. Radiotherapy is often accompanied by early and late toxicity and side effects and narrow therapeutic window. Similarity in radiation absorption properties of tumors and neighboring healthy tissues is often the reason for low specificity of radiation therapy. Development ...

Objective(s): Semiconductor zinc oxide nanoparticles (ZnO NPs) have unique properties, such as inherent selectivity and photosensitization effects under ultraviolet (UV) radiation. ZnO NPs serve as promising anticancer agents. However, UV radiation limits their penetration into the body. In most clinical settings, it is essential to use high-energy photons in the treatment of deep-seated tumors...

The goal of this study is to evaluate the effects of intermediate megavoltage (3-MV) photon beams on SBRT lung cancer treatments. To start with, a 3-MV virtual beam was commissioned on a commercial treatment planning system based on Monte Carlo simulations. Three optimized plans (6-MV, 3-MV and dual energy of 3- and 6-MV) were generated for 31 lung cancer patients with identical beam configurat...

The dose distributions for a patient with cancer involving the sternum were calculated for both a kilovoltage x-ray beam and a megavoltage electron beam. The minimum target dose and dose uniformity over the target volume were significantly better using electrons (90%-101%) than kilovoltage x-rays (68%-119%). The calculated lung dose and integral patient dose were also less for electrons than ki...

introduction: globally, the need for radiotherapy as a part of cancer management increases every year. thus, the shielding for megavoltage radiotherapy rooms is of great importance. materials and methods: in the present study, 14 types of developed high-density concrete with densities ranging from 2.45 to 5.11 were simulated by using monte carlo method. the linear attenuation coefficient and th...

Introduction: Globally, the need for radiotherapy as a part of cancer management increases every year. Thus, the shielding for megavoltage radiotherapy rooms is of great importance. Materials and Methods: In the present study, 14 types of developed high-density concrete with densities ranging from 2.45 to 5.11 were simulated by using Monte Carlo method. The linear attenuation coefficient and t...

Helical tomotherapy is a new form of image-guided radiation therapy that combines features of a linear accelerator and a helical computed tomography (CT) scanner. Megavoltage CT (MVCT) data allow the verification and correction of patient setup on the couch by comparison and image registration with the kilovoltage CT multi-slice images used for treatment planning. An 84-year-old male patient wi...

Megavoltage electron beams represent an important treatment modality in modern radiotherapy, often providing a unique option in the treatment of superficial tumours (less than 5 cm deep). Electrons have been used in radiotherapy since the early 1950s, first produced by betatrons and then by microtrons and linacs. Modern high energy linacs typically provide, in addition to two megavoltage photon...

Objective(s):The current systematic study has reviewed the therapeutic potential of gold nanoparticles as nano radiosensitizers for cancer radiation therapy.   Materials and Methods: This study was done to review nano radiosensitizers. PubMed, Ovid Medline, Science Direct, SCOPUS, ISI web of knowledge, Springer databases were searched from 2000 to September 2013 to identify appropriate studies....