نتایج جستجو برای: Mefloquine

تعداد نتایج: 976  

Effat Souri, Hassan Farsam, Massoud Amanlou, Mehdi Nateghpour, Yaghob Hamedi, Zahra Kaji,

The in vitro activity of rac-mefloquine hydrochloride and its pure enantiomers was tested against a chloroquine-resistant (PF.IBS2) strain of Plasmodium falciparum. The parasite isolated from Iranian patients was cultured in vitro by the candle jar method described by Tranger and Jensen and was exposed to the racemic mefloquine or its enantiomers over the concentration range of 10-9 to 10-4 M. ...

2010
Thomas A. van Essen Ruben S. van der Giessen Sebastiaan K. E. Koekkoek Frans VanderWerf Chris I. De Zeeuw Perry J. J. van Genderen David Overbosch Marcel T. G. de Jeu

Mefloquine (a marketed anti-malaria drug) prophylaxis has a high risk of causing adverse events. Interestingly, animal studies have shown that mefloquine imposes a major deficit in motor learning skills by affecting the connexin 36 gap junctions of the inferior olive. We were therefore interested in assessing whether mefloquine might induce similar effects in humans. The main aim of this study ...

Journal: :Neuropharmacology 2006
Joseph J McArdle Lawrence C Sellin Kathleen M Coakley Joseph G Potian Kormakur Hognason

Effectiveness against chloroquine-resistant Plasmodia makes mefloquine a widely used antimalarial drug. However, mefloquine's neurologic effects offset this therapeutic advantage. Cellular actions which might contribute to the neurologic effects of mefloquine are not understood. Structural similarity to tacrine suggested that mefloquine might alter cholinergic synaptic transmission. Therefore, ...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010
Jennifer Keiser Nicaise A N'Guessan Koffi D Adoubryn Kigbafori D Silué Penelope Vounatsou Christoph Hatz Jürg Utzinger Eliézer K N'Goran

BACKGROUND Morbidity control of schistosomiasis relies on a single drug, praziquantel. The antimalarial drug mefloquine possesses interesting antischistosomal properties, yet no clinical studies have been performed. METHODS We conducted a randomized, exploratory open-label trial to assess the efficacy and safety of mefloquine (25 mg/kg), artesunate (3 doses of 4 mg/kg), mefloquine-artesunate ...

Journal: :Antimicrobial agents and chemotherapy 1982
R Chevli C D Fitch

The new antimalarial drug mefloquine bound with high affinity (Kd approximately 3 X 10-7 M) to membrane lipids of normal mouse erythrocytes and of erythrocytes infected either with chloroquine-susceptible or chloroquine-resistant Plasmodium berghei. Approximately 80 nmol of mefloquine was bound per mg of total lipid. Mefloquine also bound to purified phospholipids with high affinity (Kd approxi...

Journal: :Antimicrobial agents and chemotherapy 2012
Luiz E Bermudez Clark B Inderlied Peter Kolonoski Christopher B Chee Priscilla Aralar Mary Petrofsky Toufan Parman Carol E Green Anita H Lewin William Y Ellis Lowell S Young

Infection caused by Mycobacterium avium is common in AIDS patients who do not receive treatment with highly active antiretroviral therapy (HAART) or who develop resistance to anti-HIV therapy. Mefloquine, a racemic mixture used for malaria prophylaxis and treatment, is bactericidal against M. avium in mice. MICs of (+)-erythro-, (-)-erythro-, (+)-threo-, and (-)-threo-mefloquine were 32 μg/ml, ...

Journal: :Lancet 1993
H O Lobel M Miani T Eng K W Bernard A W Hightower C C Campbell

The spread of chloroquine-resistant Plasmodium falciparum malaria has led to increased use of mefloquine prophylaxis by US Peace Corps volunteers in sub-Saharan Africa. We compared long-term mefloquine with other drug regimens for effectiveness and tolerance. The incidence of Plasmodium falciparum infections and of adverse reactions was compared in Peace Corps volunteers who took chloroquine we...

Journal: :The journal of the American Academy of Psychiatry and the Law 2013
Elspeth Cameron Ritchie Jerald Block Remington Lee Nevin

Mefloquine (previously marketed in the United States as Lariam®) is an antimalarial medication with potent psychotropic potential. Severe psychiatric side effects due to mefloquine intoxication are well documented, including anxiety, panic attacks, paranoia, persecutory delusions, dissociative psychosis, and anterograde amnesia. Exposure to the drug has been associated with acts of violence and...

2014
Jennifer Keiser Kigbafori D. Silué Lukas K. Adiossan Nicaise A. N'Guessan N'Chou Monsan Jürg Utzinger Eliézer K. N'Goran

BACKGROUND Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis. The antimalarial drug mefloquine shows antischistosomal activity in animal models and clinical trials, which calls for further investigations. METHODOLOGY We comparatively assessed the efficacy and tole...

Journal: :The American journal of tropical medicine and hygiene 2013
Nongluk Seethorn Walther H Wernsdorfer Harald Noedl Juntra Karbwang Kesara Na-Bangchang

The investigation of gender-specific partitioning of the antimalarial drug mefloquine to cellular and fluid blood compartments was performed using blood collected from a female and male healthy subject that were infected with Plasmodium falciparum PCM2 clone and spiked with mefloquine (0.25, 1, and 5 μM). Mefloquine concentrations in red cells of both female and male subjects were significantly...

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