www.thelancet.com/oncology Published online August 11, 2016 http://dx.doi.org/10.1016/S1470-2045(16)30390-4 1 The proportion of children with medulloblastoma receiving deferred postoperative radiotherapy more than tripled in the USA from 2004 to 2012, according to new research. Benjamin Kann (Yale University School of Medicine, New Haven, CT, USA) and colleagues examined the records of 816 pati...

introduction: orthogonal radial fields are those in which the central axes are perpendicular to each other. an example of these orthogonal fields is the set of craniospinal orthogonal fields that are used for radiotherapy of medulloblastoma. craniospinal radial fields consist of two parallel-opposed fields for brain exposure and one or two posterior spinal fields for spinal cord exposure. the m...

Medulloblastoma and primitive neuroectodermal tumors (PNETs) are the most common malignant brain tumors in children. The concern for late sequelae of neuraxis irradiation and the obligation to improve disease-free survival in children who harbor malignant brain tumors has led to the additional provision of systemic chemotherapy to standard- and reduced-dose radiotherapy, as well as to the evalu...

Multiple primitive intracranial tumors with different histological characteristics are uncommon. Although coexistence of a medulloblastoma with glial tumors has been reported in children, medulloblastoma is rarely found in adults, especially those older than 40 years of age. We present an extremely rare case of a medulloblastoma developing in a 40-year-old male undergoing maintenance chemothera...

Medulloblastoma is a malignant brain tumour most frequently seen in children. Treatment of this tumour type usually consists of surgery followed by radiotherapy. Relapses of medulloblastoma are sensitive to chemotherapy and treatment with chemotherapeutics in children has increased the survival rates. A medulloblastoma at adult age is extremely rare, and there is no overall accepted treatment, ...

Medulloblastoma (MB) is one of the most prevalent brain tumours among paediatrics. Although its management has evolved over time still there is need to find new therapeutic targets for MB that can result in less normal tissue toxicity while improving survival and reducing recurrence. This literature review is aimed at finding new potential therapeutic targets for MB focusing on viruses that can...

medulloblastoma is quite uncommon in the adult population and even rarer in extra-axial site in cerebello- pontine (cp) angle. in this report, a 23-year-old male patient with a two month history of deafness, nausea, vomiting and ataxia is presented. clinical and radiological findings demonstrated a heterogeneously enhanced extra-axial lesion in the right cp angle. total excision was performed a...

Abstract We show the therapeutic potential of myeloid-directed immunomodulatory treatment for medulloblastoma. Patients with medulloblastoma, most common malignant pediatric brain tumor, need new treatments, as standard therapy produces disabling neurotoxicities and fails 20% patients. About 30% medulloblastomas hyperactivation SHH (Sonic Hedgehog) signaling pathway, these tumors have large mye...

Medulloblastoma is the most common malignant brain tumor of childhood. Novel therapeutic strategies are urgently needed to overcome cytotoxic resistance. We hypothesized that antiapoptotic signals contribute to resistance and that treatment with proapoptotic agents could increase the efficacy of conventional therapies. A PCR array was used to assess the status of the apoptotic signaling pathway...

  Medulloblastoma is quite uncommon in the adult population and even rarer in extra-axial site in cerebello-   pontine (CP) angle. In this report, a 23-year-old male patient with a two month history of deafness, nausea, vomiting and ataxia is presented. Clinical and radiological findings demonstrated a heterogeneously enhanced extra-axial lesion in the right CP angle. Total excision was perform...