Linear Discriminant Analysis (LDA) is an important dimensionality reduction algorithm, but its performance is usually limited on multi-class data. Such limitation is incurred by the fact that LDA actually maximizes the average divergence among classes, whereby similar classes with smaller divergence tend to be merged in the subspace. To address this problem, we propose a novel dimensionality re...

Research on large margin classifiers from the "local" and "global" view has become an active topic in machine learning and pattern recognition. Inspired from the typical local and global learning machine Maxi-Min Margin Machine (M⁴) and the idea of the Locality Preserving Projections (LPP), we propose a novel large margin classifier, the Generalized Locality Preserving Maxi-Min Margin Machine (...

The effects of different freezing and thawing rates on the post-thaw motility and membrane integrity of boar spermatozoa, processed as split samples in Maxi-straws or flat PET-plastic packages (FlatPack) were studied. A programmable freezing device was used to obtain freezing rates of either 20, 50 or 80 degrees C/min. Thawing of the samples was performed in a bath of circulating water; for 40s...

Desensitization of ANG II tonic contractile response of the guinea pig ileum is related to membrane repolarization determined by Ca2+-activated K+(maxi-K+) channel opening. ANG II-stimulated depolarized myocytes presented sustained activation of maxi-K+ channels, characterized by reduction from 415 to 12 ms of the closed time constant. ANG II desensitization was prevented by 100 nM iberiotoxin,...

This study was carried out to obtain informations regarding the effect of N-acetyl-D-glucosamine in the LEY (lactoseegg yolk) diluent according to incubation time in 5 ml maxi-straw and the effects of freezing rate, thawing temperature and thawing time in the LEN (lactose-egg yolk and N-acetyl-D-glucosamine) diluent on acrosome morphology and motility of frozen-thawed boar sperm. The study show...

A general purpose medical image retrieval framework has been proposed with two subsystems namely enrollment and the query subsystem. As an attempt to design a new content based image retrieval methodology following the above framework, MAXI-MIN approach is implemented for the ultra sound kidney images for the retrieval process. Around hundred ultrasound kidney images have been collected from th...

WNK [with no lysine (k)] kinase is a serine/threonine kinase subfamily. Mutations in two of the WNK kinases result in pseudohypoaldosteronism type II (PHA II) characterized by hypertension, hyperkalemia, and metabolic acidosis. Recent studies showed that both WNK1 and WNK4 inhibit ROMK activity. However, little is known about the effect of WNK kinases on Maxi K, a large-conductance Ca(2+) and v...

The maxi-anion channel plays a classically recognized role in controlling the membrane potential through the chloride conductance. It also has novel functions as a regulated pathway for the release of the anionic signaling molecules ATP and excitatory amino acids from cells subjected to osmotic perturbation, ischemia, or hypoxia. Because hemichannels formed by pannexins and connexins have been ...