background: the risk of gestational diabetes mellitus (gdm) in accordance to body mass index (bmi) is often based on studies where the calculation of bmi is frequently self-reported and is usually unreliable. we evaluated the risk of an abnormal oral glucose tolerance test (ogtt) in a population where bmi was measured and selective screening for gdm was practiced. methods: we carried out a pros...

Background: Many factors affect exclusive breastfeeding, include method of delivery, parity, maternal age and education, smoking, ethnicity, pregnancy complications, infant health, and environmental factors such as hospital practices, and social support. Recently, maternal obesity has been suggested as a risk factor for poor breast-feeding practices whose role has not...

Maternal obesity is known to increase the risk of obesity and diabetes in offspring. Though diabetes is a key risk factor for the development of chronic kidney disease (CKD), the relationship between maternal obesity and CKD has not been clearly defined. In this study, a mouse model of maternal obesity was employed to determine the impact of maternal obesity on development of diabetic nephropat...

OBJECTIVE Obesity is associated with alterations in thyroid hormone (TH) levels in obese, pregnant individuals. The maintenance of TH levels throughout gestation is important for proper foetal development. The aim of this study was to measure levels of fT3, fT4 and TSH in maternal and matched cord blood serum from normal weight, overweight and obese gravidae to determine alterations in maternal...

BACKGROUND Maternal obesity is emerging as a public health problem, recently highlighted together with maternal under-nutrition as a 'double burden', especially in African countries undergoing social and economic transition. This systematic review was conducted to investigate the current evidence on maternal obesity in Africa. METHODS MEDLINE, EMBASE, Scopus, CINAHL and PsycINFO were searched...

OBJECTIVE Limited data exist on the association between in utero exposure to maternal diabetes and obesity and type 2 diabetes in diverse youth. These associations were explored in African-American, Hispanic, and non-Hispanic white youth participating in the SEARCH Case-Control Study. RESEARCH DESIGN AND METHODS A total of 79 youth with type 2 diabetes and 190 nondiabetic control youth aged 1...

Maternal obesity is a global health problem that increases offspring obesity risk. The metabolic pathways underlying early developmental programming in human infants at risk for obesity remain poorly understood, largely due to barriers in fetal/infant tissue sampling. Utilizing umbilical cord-derived mesenchymal stem cells (uMSC) from offspring of normal weight and obese mothers, we tested whet...