Gotham's disease or vanishing bone is a rare disease with unknown etiology. Frequently, children and young adults are affected. It is characterized by proliferation of vascular or lymphatic tissue which results in destruction and resorption of bone. In this disease, the destructed bone is replaced either by hemangiomatous or lymphangiomatous tissue ( s) and in a later stage, fibrosis occurs. It...

Chylothorax may rarely occur in osteolysis. A fatal case of bilateral chylothorax complicating massive osteolysis is described and the pathogenesis and management are discussed.

The Gorham-Stout Syndrome (Gorham's massive osteolysis) is a rare condition in which spontaneous, progressive resorption of bone occurs. The aetiology is poorly understood. We report six cases of the condition and present evidence that osteolysis is due to an increased number of stimulated osteoclasts. This suggests that early potent antiresorptive therapy such as with calcitonin or bisphosphon...

We report two cases of suspected massive osteolysis Case 1 was a 63-year-old man who experienced pain in his left buttock six years ago and was walking with a limp the following year. X-ray showed resorption of the left coxal bone and pubic bone. Suspecting a malignant tumor, biopsy was performed. The findings showed massive osteolysis which had destroyed bone trabeculaes, and replaced granulom...