Background: Mannitol is present in the Ethyol ® (the trade name of amifostine) as an excipient. The mechanism of radioprotection of amifostine is radical scavenging. Since mannitol is another known radical scavenger, we studied the probable additive or synergistic effect of mannitol on the effect of amifostine. Material and Methods: Mice were irradiated with Co-60 γ -ray in the presence 400mg/k...

background: mannitol is present in the ethyol ® (the trade name of amifostine) as an excipient. the mechanism of radioprotection of amifostine is radical scavenging. since mannitol is another known radical scavenger, we studied the probable additive or synergistic effect of mannitol on the effect of amifostine. material and methods: mice were irradiated with co-60 γ -ray in the presence 400mg/k...

δ-mannitol is a metastable polymorph of mannitol, known for its superior tableting properties. However, there no easy, reproducible and scalable production method δ-mannitol. It was evaluated whether could be formed via co-spray drying with an API exhibiting tabletability issues, to improve the in one-step process prior compaction. Aqueous suspensions paracetamol β-mannitol were dried. Raman sp...

tilmicosin (tlm) is an important antibiotic in veterinary medicine with low bioavailability and safety. this study aimed to formulate and evaluate physicochemical properties, storage stability after lyophilization and antibacterial activity of three tlm-loaded lipid nanoparticles (tlm-lnps) including solid lipid nanoparticles (slns), nanostructured lipid carriers (nlcs) and lipid-core nanocapsu...

Mannitol, a common pharmaceutical ingredient, exhibits complex polymorphism even in simple binary mannitol/water mixtures, with four crystalline forms observed. In this investigation, time/temperature-resolved synchrotron X-ray diffraction measurements are performed during freezing and thawing of mixtures. Mannitol crystallization depends strongly on the cooling rate is initiated cooling, if lo...

Mannitol may be useful clinically both as a diuretic and as an obligate extracellular solute. As a diuretic it can be used to treat patients with intractable edema states, to increase urine flow and flush out debris from the renal tubules in patients with acute tubular necrosis, and to increase toxin excretion in patients with barbiturate, salicylate or bromide intoxication. As an obligate extr...

Numerous plants and fungi produce mannitol, which may serve as an osmolyte or metabolic store; furthermore, mannitol also acts as a powerful quencher of reactive oxygen species (ROS). Some phytopathogenic fungi use mannitol to stifle ROS-mediated plant resistance. Mannitol is essential in pathogenesis to balance cell reinforcements produced by both plants and animals. Mannitol likewise serves a...

To achieve high mannitol production by Lactococcus lactis, the mannitol 1-phosphatase gene of Eimeria tenella and the mannitol 1-phosphate dehydrogenase gene mtlD of Lactobacillus plantarum were cloned in the nisin-dependent L. lactis NICE overexpression system. As predicted by a kinetic L. lactis glycolysis model, increase in mannitol 1-phosphate dehydrogenase and mannitol 1-phosphatase activi...